University of Oulu

Catherine Bueno Domingueti, Dayana Aparecida Queiroz Castilho, Carine Ervolino de Oliveira, João Baptista Macuco Janini, Wilfredo Alejandro González-Arriagada, Tuula Salo, Ricardo D. Coletta, Lívia Máris Ribeiro Paranaíba, Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 130, Issue 6, 2020, Pages 700-707.e2, ISSN 2212-4403, https://doi.org/10.1016/j.oooo.2020.09.003

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

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Author: Domingueti, Catherine Bueno1; Queiroz Castilho, Dayana Aparecida1; de Oliveira, Carine Ervolino1;
Organizations: 1Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil
2Institute of Diagnostic and Prevention (IPD Laboratory), Varginha, Minas Gerais, Brazil
3Centro de Investigación en Ciencias Odontológicas y Médicas, Facultad de Odontología, Universidad de Valparaíso, Valparaíso, Chile
4Cancer and Translational Medicine Research Unit, Faculty of Medicine and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
5Institute of Oral and Maxillofacial Disease, University of Helsinki, and HUSLAB, Department of Pathology, Helsinki University Hospital, Helsinki, Finland
6Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe20201221101635
Language: English
Published: Elsevier, 2020
Publish Date: 2021-09-15
Description:

Abstract

Objective: Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis.

Study Design: Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination.

Results: High expression of EEF1D (P = 0.017) and PINP (P = 0.02) and abundant density of CAFs in tumor stroma (P = 0.005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival.

Conclusions: Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.

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Series: Oral surgery, oral medicine, oral pathology and oral radiology
ISSN: 2212-4403
ISSN-E: 2212-4411
ISSN-L: 2212-4403
Volume: 130
Issue: 6
Pages: 700 - 707.e2
DOI: 10.1016/j.oooo.2020.09.003
OADOI: https://oadoi.org/10.1016/j.oooo.2020.09.003
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Funding: This work was supported by grants from FAPEMIG (APQ 00205.16 for Paranaíba, LMR) and FONDECYT (11140507 for González-Arriagada, WA).
Copyright information: © 2020 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/