University of Oulu

Bello, IO, Wennerstrand, PM, Suleymanova, I, Siponen, M, Qannam, A, Nieminen, P, Leivo, I, Almangush, A, Salo, T. Biopsy quality is essential for preoperative prognostication in oral tongue cancer. APMIS. 2021; 129: 118– 127. https://doi.org/10.1111/apm.13104

Biopsy quality is essential for preoperative prognostication in oral tongue cancer

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Author: Bello, Ibrahim O.1,2; Wennerstrand, Pia M.2; Suleymanova, Ilida3;
Organizations: 1Department of Oral Medicine and Diagnostic Sciences, King Saud University, Riyadh, Saudi Arabia
2Department of Pathology, University of Helsinki, Helsinki, Finland
3Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
4Institute of Dentistry, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
5Oral Health Teaching Clinic and Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
6Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland
7Institute of Biomedicine, Pathology, University of Turku, Turku, Finland
8Faculty of Dentistry, University of Misurata, Misurata, Libya
9Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe202101081361
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-12-15
Description:

Abstract

A role for incisional biopsy in preoperative prognostication is increasingly being advocated in oral tongue squamous cell carcinomas (OTSCC). Biopsies at two locations were compared, and prognostic factors in biopsies and their corresponding resections were evaluated. A total of 138 OTSCC biopsy slides from Finland and Saudi Arabia were compared for size (horizontal and vertical) and invasive front. The Finnish cases were assessed for tumor stroma ratio (TSR) and tumor‐infiltrating lymphocytes (TILs) using light microscopy and digital image analysis assessment and compared. Furthermore, TSR, TILs, and previously analyzed budding and depth of invasion (BD) score in biopsies were compared with their evaluation in the corresponding resections. Fifty‐nine percent of Finnish and 42% of Saudi Arabian biopsies were ≥ 5 mm deep, while 98% of Saudi Arabian and 76% of Finnish biopsies were ≥ 5 mm wide. Assessment of invasion front was possible in 72% of Finnish in comparison with 40% of Saudi Arabian biopsies. There was 86.8% agreement between TSR and 75% agreement between TIL evaluation using light microscopy and digital assessment. Significant agreement was obtained on comparing the TSR (p = 0.04) and BD (p < 0.001) values in biopsies and resections. Biopsies of ≥ 5 mm depth from representative OTSCC areas are essential for prognostic information. Clinical pathologists are advised to assess BD score and TSR for prognostic features in such biopsies.

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Series: APMIS
ISSN: 0903-4641
ISSN-E: 1600-0463
ISSN-L: 0903-4641
Volume: 129
Issue: 3
Pages: 118 - 127
DOI: 10.1111/apm.13104
OADOI: https://oadoi.org/10.1111/apm.13104
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Copyright information: © 2020 APMIS. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Bello, IO, Wennerstrand, PM, Suleymanova, I, Siponen, M, Qannam, A, Nieminen, P, Leivo, I, Almangush, A, Salo, T. Biopsy quality is essential for preoperative prognostication in oral tongue cancer. APMIS. 2021; 129: 118– 127, which has been published in final form at https://doi.org/10.1111/apm.13104. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."