University of Oulu

Wahab A, Almangush A, Andersson LC, Nieminen P and Salo T (2020) Impact of Astroprincin (FAM171A1) Expression in Oral Tongue Cancer. Front. Oral. Health 1:599421. doi: 10.3389/froh.2020.599421

Impact of astroprincin (FAM171A1) expression in oral tongue cancer

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Author: Wahab, Awais1,2; Almangush, Alhadi1,3,3,4; Andersson, Leif C.1;
Organizations: 1Department of Pathology, University of Helsinki, Helsinki, Finland
2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
4Faculty of Dentistry, University of Misurata, Misurata, Libya
5Medical Informatics and Statistics Research Group, University of Oulu, Oulu, Finland
6Cancer and Translational Medicine Research Unit, Medical Research Centre Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
7Translational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.9 MB)
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Language: English
Published: Frontiers Media, 2020
Publish Date: 2021-01-11


Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size (P = 0.013) and with OTSCC recurrence (P = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression.

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Series: Frontiers in oral health
ISSN: 2673-4842
ISSN-E: 2673-4842
ISSN-L: 2673-4842
Volume: 1
Article number: 599421
DOI: 10.3389/froh.2020.599421
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Funding: This study was supported by a grant from the Helsinki University Hospital Research Fund, the Sigrid Juselius Foundation, and the Cancer Society of Finland.
Copyright information: © 2020 Wahab, Almangush, Andersson, Nieminen and Salo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.