Kemi, N., Hiltunen, N., P. Väyrynen, J., Pohjanen, V.-M., Helminen, O., Junttila, A., … H. Kauppila, J. (2020). Immune Cell Infiltrate and Prognosis in Gastric Cancer. Cancers, 12(12), 3604. doi:10.3390/cancers12123604
Immune cell infiltrate and prognosis in gastric cancer
|Author:||Kemi, Niko1; Hiltunen, Niko1; Väyrynen, Juha P.1,2;|
1Cancer and Translational Medicine Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, 90220 Oulu, Finland
2Department of Pathology, Central Finland Central Hospital, 40620 Jyväskylä, Finland
3Department of Surgery, Central Finland Central Hospital, 40620 Jyväskylä, Finland
4Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33520 Tampere, Finland
5Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 17177 Stockholm, Sweden
|Online Access:||PDF Full Text (PDF, 1.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202101202188
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2021-01-20
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade. Cox regression with adjustment for confounders provided hazard ratios (HRs) and 95% CIs. Subgroup analyses were performed in intestinal and diffuse type subgroups. The primary outcome was 5-year overall survival. Results: High ICS was associated to longer 5-year survival (adjusted HR 0.70, 95% CI 0.52–0.94), compared to low ICS. The difference was significant in intestinal type subgroup (adjusted HR 0.54, 95% CI 0.36–0.81) but not in diffuse type subgroup (adjusted HR 0.92, 95% CI 0.58–1.46). High KM grade was an independent prognostic factor for longer 5-year overall survival (adjusted HR 0.59, 95% CI 0.45–0.77) in both intestinal (adjusted HR 0.61, 95% CI 0.44–0.85) and diffuse subgroups (adjusted HR 0.52, 95% CI 0.31–0.86). ICS and KM grade were moderately correlated (ρ = 0.425). When both immune cell score and KM grade were included in the regression analysis, only KM grade remained prognostic. Conclusions: Both ICS and KM grade are prognostic factors in gastric adenocarcinoma, but immunohistochemistry-based ICS might not have additional prognostic value over hematoxylin–eosin-based KM grade.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This research was funded by Vatsatautien tutkimussäätiö grant number N/A, The Finnish Medical Foundation grant number N/A, Sigrid Jusélius Foundation grant number N/A, Finnish Cancer Foundation grant number N/A, Orion Research Foundation grant number N/A, Thelma Mäkikyrö Foundation grant number N/A, Mary and Georg C. Ehrnroot Foundation grant number N/A and Instrumentarium Science Foundation grant number N/A.
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