University of Oulu

Filetti, V., Vitale, E., Broggi, G., Hagnäs, M.P., Candido, S., Spina, A., & Lombardo, C. (2020). Update of in vitro, in vivo and ex vivo fluoro‑edenite effects on malignant mesothelioma: A systematic review (Review). Biomedical Reports, 13, 60.

Update of in vitro, in vivo and ex vivo fluoro‑edenite effects on malignant mesothelioma : a systematic review (Review)

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Author: Filetti, Veronica1; Vitale, Ermanno2; Broggi, Giuseppe3;
Organizations: 1Anatomy and Histology, Department of Biomedical and Biotechnological Sciences
2Occupational Medicine, Department of Clinical and Experimental Medicine
3Pathologic Anatomy, Department ‘G.F. Ingrassia’, University of Catania, I‑95123 Catania, Italy
4Rovaniemi Health Centre, 96200 Rovaniemi
5Center for Life Course Health Research, University of Oulu, 90150 Oulu, Finland
6Oncologic, Clinic and General Pathology Section, Department of Biomedical and Biotechnological Sciences
7Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, I‑95123 Catania
8INPS Italian National Social Security Institution, I‑95129 Catania, Italy
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link:
Language: English
Published: Spandidos Publications, 2020
Publish Date: 2021-01-27


Fluoro‑edenite (FE), asbestiform fiber found in Biancavilla (Sicily, Italy), presents various characteristics similar to the asbestos group, in particular two fibrous phases tremolite and actinolite. Indeed, epidemiological studies have shown that FE fibers have similar effects to those of asbestos fibers. Such studies have reported a high incidence of malignant mesothelioma (MM), an aggressive neoplasm of the serosal membranes lining the pleural cavity, in individuals residing there due to FE exposure in Biancavilla related to environmental contamination. Evidence has led to the classification of FE as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC). The aim of this systematic review is to compare the results achieved in in vitro, in vivo and ex vivo experimental studies involving FE in order to update the current knowledge on the pathogenesis and molecular mechanisms responsible for FE‑mediated MM development as well as the availability of effective biomarkers for MM prevention and diagnosis. This review is focused on the pathophysiological mechanisms mediated by inflammation induced by FE fiber exposure and which are responsible for MM development. This review also discusses the discovery of new diagnostic and prognostic biomarkers for the management of this pathology. It is known that the risk of cancer development increases with chronic inflammation, arising from enhanced reactive oxygen species (ROS) and NO production stimulated by the body to remove exogenous agents, causing DNA damage and enhanced signal transduction that may lead to activation of oncogenes. Studies concerning MM biomarker discovery indicate that several biomarkers have been proposed for MM, but mesothelin is the only Food and Drug Administration (FDA)‑approved biomarker for MM, with limitations. In recent studies, in silico analysis to identify selected miRNAs highly deregulated in cancer samples when compared with normal control have been developed. This in silico approach could represent an effort in the field of biomarker discovery for MM.

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Series: Biomedical reports
ISSN: 2049-9434
ISSN-E: 2049-9442
ISSN-L: 2049-9434
Volume: 13
Issue: 6
Pages: 1 - 11
Article number: 60
DOI: 10.3892/br.2020.1367
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Copyright information: © Filetti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.