University of Oulu

Tegelberg, P., Tervonen, T., Knuuttila, M., Jokelainen, J., Keinänen‐Kiukaanniemi, S., Auvinen, J. and Ylöstalo, P. (2021), Association of hyperglycaemia with periodontal status: Results of the Northern Finland Birth Cohort 1966 study. J Clin Periodontol, 48: 25-37. https://doi.org/10.1111/jcpe.13388

Association of hyperglycaemia with periodontal status : results of the Northern Finland Birth Cohort 1966 study

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Author: Tegelberg, Paula1; Tervonen, Tellervo1; Knuuttila, Matti2;
Organizations: 1Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
2Department of Oral and Maxillofacial Surgery, Oulu University Hospital, Oulu, Finland
3Center for Life Course Epidemiology and Systems Medicine, University of Oulu and Unit of Primary Care, Oulu, Finland
4Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
5Healthcare and Social Services of Selänne, Pyhäjärvi, Finland
6Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Health Centre of Oulu, Oulu, Finland
7Oulunkaari Health Centre, Ii, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe202102023546
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-10-13
Description:

Abstract

Aim: To investigate the association of hyperglycaemia and changes in glycaemic control with periodontal status in non‐diabetic individuals.

Materials and methods: A sub‐population (n = 647) of the Northern Finland Birth Cohort 1966 was studied. We categorized long‐term glucose balance based on fasting plasma glucose (FPG) at ages 31 and 46: FPG <5.0 mmol/l (strict normoglycaemia), FPG 5.0–5.59 mmol/l (slightly elevated FPG) and FPG 5.6–6.9 mmol/l (prediabetes). Probing pocket depth (PPD) and alveolar bone level (BL) data were collected at age 46. Relative risks (RR, 95% CI) were estimated using Poisson regression models.

Results: Periodontal status was poorer in individuals whose glucose balance worsened from age 31 to 46 years than in those with a stable glucose balance. In the case of strict normoglycaemia at age 31 and slightly elevated FPG or prediabetes at age 46, the RRs for PPD ≥4 mm were 1.8 (95% CI 1.4–2.2) and 2.8 (95% CI 2.0–3.8) and for BL ≥5 mm 1.1 (95% CI 0.8–1.4) and 1.8 (95% CI 1.2–2.8), respectively.

Conclusion: The results of this population‐based cohort study suggest that impairment in glucose control in non‐diabetic individuals is associated with periodontal pocketing and alveolar bone loss.

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Series: Journal of clinical periodontology
ISSN: 0303-6979
ISSN-E: 1600-051X
ISSN-L: 0303-6979
Volume: 48
Issue: 1
Pages: 25 - 37
DOI: 10.1111/jcpe.13388
OADOI: https://oadoi.org/10.1111/jcpe.13388
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: The present study is part of the Northern Finland Birth Cohort 1966 study.
Copyright information: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Tegelberg, P., Tervonen, T., Knuuttila, M., Jokelainen, J., Keinänen‐Kiukaanniemi, S., Auvinen, J. and Ylöstalo, P. (2021), Association of hyperglycaemia with periodontal status: Results of the Northern Finland Birth Cohort 1966 study. J Clin Periodontol, 48: 25-37, which has been published in final form at https://doi.org/10.1111/jcpe.13388. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.