Loss of USF2 promotes proliferation, migration and mitophagy in a redox-dependent manner |
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Author: | Chi, Tabughang Franklin1; Khoder-Agha, Fawzi1; Mennerich, Daniela1; |
Organizations: |
1Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 5.6 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe202102033592 |
Language: | English |
Published: |
Elsevier,
2020
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Publish Date: | 2021-02-03 |
Description: |
AbstractThe upstream stimulatory factor 2 (USF2) is a transcription factor implicated in several cellular processes and among them, tumor development seems to stand out. However, the data with respect to the role of USF2 in tumor development are conflicting suggesting that it acts either as tumor promoter or suppressor. Here we show that absence of USF2 promotes proliferation and migration. Thereby, we reveal a previously unknown function of USF2 in mitochondrial homeostasis. Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT. Altogether, this study supports USF2′s function as tumor suppressor and highlights its novel role for mitochondrial function and energy homeostasis thereby linking USF2 to conditions such as insulin resistance, type-2 diabetes mellitus, and the metabolic syndrome. see all
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Series: |
Redox biology |
ISSN: | 2213-2317 |
ISSN-E: | 2213-2317 |
ISSN-L: | 2213-2317 |
Volume: | 37 |
Article number: | 101750 |
DOI: | 10.1016/j.redox.2020.101750 |
OADOI: | https://oadoi.org/10.1016/j.redox.2020.101750 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
1182 Biochemistry, cell and molecular biology |
Subjects: | |
Funding: |
This work was supported by the Academy of Finland SA296027, the Jane and Aatos Erkko Foundation, the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the University of Oulu, and Biocenter Oulu. |
Academy of Finland Grant Number: |
296027 |
Detailed Information: |
296027 (Academy of Finland Funding decision) |
Copyright information: |
© 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |