University of Oulu

Burman, J, Malmberg, P, Elenius, V, et al. Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children. Clin Physiol Funct Imaging. 2020; 41: 1– 3. https://doi.org/10.1111/cpf.12673

Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children

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Author: Burman, Janne1; Malmberg, Pekka1; Elenius, Varpu2;
Organizations: 1Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
2Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
3Department of Physics and Astronomy, University of Turku, Turku, Finland
4Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland
5Department of Paediatrics, Oulu University Hospital and University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe202102043706
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-10-27
Description:

Abstract

Background: Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited.

Aim: We aimed to evaluate whether EVH tests affect the level of FeNO in children aged 10–16 years.

Methods: A total of 234 children aged 10–16 years had a 6‐min EVH test performed. In total, FeNO values for 153 of 234 children were measured before the test and within 15 min after the test. According to a baseline FeNO level of 20 ppb, children were divided into two groups: those with low values (FeNO < 20 ppb) and those with high values (FeNO ≥ 20 ppb).

Results: The median age of the children was 13.4 years (interquartile range 12.3–15.3 years); 58% were boys and 42% were girls. Of these children, 51% were sensitized to aeroallergens. In 101 of 153 children (66%), the FeNO values decreased after the EVH test. In children with low and high baseline levels, the median level of FeNO decreased after the EVH test: 10.5 ppb before versus 9.5 ppb after (p < .011), and 31.0 ppb before versus 28.0 ppb after (p < .011), respectively. The decrease in FeNO after EVH test was not associated with induced bronchoconstriction expressed as a change in FEV1 (Rs = .19).

Conclusions: The EVH test decreases FeNO levels. Therefore, FeNO should be measured before an EVH test is performed.

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Series: Clinical physiology and functional imaging
ISSN: 1475-0961
ISSN-E: 1475-097X
ISSN-L: 1475-0961
Volume: 41
Issue: 1
Pages: 1 - 3
DOI: 10.1111/cpf.12673
OADOI: https://oadoi.org/10.1111/cpf.12673
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: Suomen Kulttuurirahasto; Allergiasäätiö; Kerttu and Kalle Wiik Foundation; Jalmari ja Rauha Ahokkaan Säätiö.
Copyright information: © 2020 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Burman, J, Malmberg, P, Elenius, V, et al. Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children. Clin Physiol Funct Imaging. 2020; 41: 1– 3, which has been published in final form at https://doi.org/10.1111/cpf.12673. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."