Kauppila JH, Ohtonen P, Rantanen T, et al. Cohort profile: gastric cancer in the population-based, Finnish National Esophago-Gastric Cancer Cohort (FINEGO) Study. BMJ Open 2020;10:e039574. doi: 10.1136/bmjopen-2020-039574
Cohort profile: gastric cancer in the population-based, Finnish National Esophago-Gastric Cancer Cohort (FINEGO) Study
|Author:||Kauppila, Joonas H.1,2; Ohtonen, Pasi2; Rantanen, Tuomo3;|
1Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
2Surgery Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Pohjois-Savo, Finland
4Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
5Department of Cardiothoracic Surgery, Heart Center, Tampere University Hospital, Tampere, Finland
6Department of General Thoracic and Oesophageal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
7Department of Oncology and Haematology, Oulu University Hospital, Oulu, Finland
8Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland
9Cancer and Translational Medicine Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
10Department of Pathology, HUSLAB, Helsinki, Finland
11Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki and Helsinki University Hospital, Oulu, Finland
12The Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland
13Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202102124614
|Publish Date:|| 2021-02-12
Purpose: The Finnish National Esophago-Gastric Cancer Cohort (FINEGO) was established with the aim of identifying factors that could contribute to improved outcomes in oesophago-gastric cancer. The aim of this study is to describe the patients with gastric cancer included in FINEGO.
Participants: A total of 10 457 patients with gastric cancer or tumour diagnosis in the Finnish Cancer Registry or the Finnish Patient Registry during 1987–2016 were included in the cohort, with follow-up from Causes of Death Registry until 31 December 2016. All of the participants were at least 18 years of age, and had undergone either resectional or endoscopic mucosal surgery with curative or palliative intent.
Findings: to date Of the 10 457 patients, 90.1% were identified to have cancer in both cancer and patient registries. In all, the median age was 70 at the time of surgery, 54.5% of the patients were men and 64.4% had no comorbidities. Education data were available for 31.1% of the patients, of whom the majority had had <12 years of formal education. Of the 7798 with cancer staging data available, 41.1% had a local cancer. Adenocarcinoma was the most common (94.2%) histological type. Almost all patients underwent open gastrectomy and 214% in hospitals with annual volume of more than 30 gastrectomies per year. A total of 8561 deaths occurred during the study period, of which 6474 were due to oesophago-gastric cancers. The 5-year survival was 34.6% and 5-year cancer-specific survival was 39.7%.
Future plans: The data in FINEGO can be currently used for registry-based research but is being expanded by data extraction from patient records and scanning of histological samples from the Finnish biobanks. Initially, we are planning on studies on the national trends in treatment and mortality, and studies on the demographic factors and their influence on survival.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work is supported by research grants from the Sigrid Jusélius Foundation (Sigrid Juséliuksen Säätiö), The Finnish Cancer Foundation (Syöpäsäätiö), Päivikki and Sakari Sohlberg Foundation and Orion Research Foundation (Orionin Tutkimussäätiö).
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/