University of Oulu

Thudium, C.S., Nielsen, S.H., Sardar, S. et al. Bone phenotypes in rheumatology – there is more to bone than just bone. BMC Musculoskelet Disord 21, 789 (2020).

Bone phenotypes in rheumatology : there is more to bone than just bone

Saved in:
Author: Thudium, Christian S.1; Holm Nielsen, Signe1,2; Sardar, Samra1;
Organizations: 1Nordic Bioscience, Herlev Hovedgade, 205-207, Herlev, Denmark
2Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
4Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
5Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
6Centre for Sport, Exercise and Osteoarthritis Versus Arthritis, Queen’s, Medical Centre, Nottingham, UK
7Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands
8Department Of Rheumatology, Dijklander Hospital, Hoorn, The Netherlands
9Skeletal Biology and Engineering Research Center, Laboratory of Tissue Homeostasis and Disease, KU Leuven, Leuven, Belgium
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.7 MB)
Persistent link:
Language: English
Published: Springer Nature, 2020
Publish Date: 2021-02-12


Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change in bone matrix and mineral turnover. While these diseases share a common tissue axis, their manifestations in the area of pathology are highly diverse, ranging from sclerosis to erosion of bone in different regions. The management of these diseases will benefit from a deeper understanding of the local versus systemic effects, the relation to the equilibrium of the bone balance (i.e., bone formation versus bone resorption), and the physiological and pathophysiological phenotypes of the cells involved (e.g., osteoblasts, osteoclasts, osteocytes and chondrocytes). For example, the process of endochondral bone formation in chondrocytes occurs exists during skeletal development and healthy conditions, but also in pathological conditions. This review focuses on the complex molecular and cellular taxonomy of bone in the context of rheumatological diseases that alter bone matrix composition and maintenance, giving rise to different bone turnover phenotypes, and how biomarkers (biochemical markers) can be applied to potentially describe specific bone phenotypic tissue profiles.

see all

Series: BMC musculoskeletal disorders
ISSN: 1471-2474
ISSN-E: 1471-2474
ISSN-L: 1471-2474
Volume: 21
Issue: 1
Article number: 789
DOI: 10.1186/s12891-020-03804-2
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Copyright information: © The Author(s). 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.