University of Oulu

Andrey D. Bulygin, Denis A. Vrazhnov, Elena S. Sim, Igor Meglinski, and Yury V. Kistenev "Imitation of optical coherence tomography images by wave Monte Carlo-based approach implemented with the Leontovich–Fock equation," Optical Engineering 59(6), 061626 (28 February 2020).

Imitation of optical coherence tomography images by wave Monte Carlo-based approach implemented with the Leontovich-Fock equation

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Author: Bulygin, Andrey D.1,2; Vrazhnov, Denis A.1,3; Sim, Elena S.1;
Organizations: 1National Research Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia
2V.E. Zuev Institute of Atmospheric Optics SB RAS, Laboratory of Nonlinear Optical Interactions, Tomsk, Russia
3Institute of Strength Physics and Materials Science SB RAS, Laboratory of Molecular Imaging and Photoacoustics, Tomsk, Russia
4University of Oulu, Optoelectronics and Measurement Techniques Laboratory, Oulu, Finland
5Aston University, School of Engineering and Applied Science, Birmingham, United Kingdom
6Aston University, School of Life and Health Sciences, Birmingham, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
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Language: English
Published: SPIE, 2020
Publish Date: 2021-02-19


We present a computational modeling approach for imitation of the time-domain optical coherence tomography (OCT) images of biotissues. The developed modeling technique is based on the implementation of the Leontovich–Fock equation into the wave Monte Carlo (MC) method. We discuss the benefits of the developed computational model in comparison to the conventional MC method based on the modeling of OCT images of a nevus. The developed model takes into account diffraction on bulk-absorbing microstructures and allows consideration of the influence of the amplitude–phase profile of the wave beam on the quality of the OCT images. The selection of optical parameters of modeling medium, used for simulation of optical radiation propagation in biotissues, is based on the results obtained experimentally by OCT. The developed computational model can be used for imitation of the light waves propagation both in time-domain and spectral-domain OCT approaches.

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Series: Optical engineering
ISSN: 0091-3286
ISSN-E: 1560-2303
ISSN-L: 0091-3286
Volume: 59
Issue: 6
Article number: 061626
DOI: 10.1117/1.OE.59.6.061626
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: This work was done using resources of the Collective Use Center, Siberian Super Computer Center of the Siberian Branch of the Russian Academy of Sciences. This work was partly supported by the Russian Foundation for Basic Research (Grant No. 17-00-00186), RFBR, and Administration of Tomsk Region (Grant Nos. 18-42-703012 and 18-41-703004). This work was carried out in the framework of the Fundamental Scientific Research Program of the State Academies of Sciences for 2013-2020, direction III.23.2.10. A.D.B., D.A.V., E.S.S., I.M., and Yu.V.K. have nothing to disclose.
Copyright information: © 2020 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2020/$28.00 © 2020 SPIE.