University of Oulu

Kajabi, AW, Casula, V, Sarin, JK, et al. Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis. J Orthop Res. 2021; 39: 63– 73.

Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

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Author: Kajabi, Abdul Wahed1,2; Casula, Victor1,2; Sarin, Jaakko K.3,4;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
5Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
6Department of Orthopaedics, University Medical Center Utrecht, the Netherlands
7School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
8Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 7 MB)
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Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-02-23


Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post‐traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of articular cartilage in PTOA. Articular explants containing surgically induced and repaired chondral lesions were obtained from the stifle joints of seven Shetland ponies (14 samples). Three age‐matched nonoperated ponies served as controls (six samples). The samples were imaged at 9.4 T. The measured qMRI parameters included T₁, T₂, continuous‐wave T (CWT), adiabatic T1ρ (AdT), and T (AdT) and relaxation along a fictitious field (TRAFF). For reference, cartilage equilibrium and dynamic moduli, proteoglycan content and collagen fiber orientation were determined. Mean values and profiles from full‐thickness cartilage regions of interest, at increasing distances from the lesions, were used to compare experimental against control and to correlate qMRI with the references. Significant alterations were detected by qMRI parameters, including prolonged T₁, CWT, and AdT in the regions adjacent to the lesions. The changes were confirmed by the reference methods. CWT was more strongly associated with the reference measurements and prolonged in the affected regions at lower spin‐locking amplitudes. Moderate to strong correlations were found between all qMRI parameters and the reference parameters (ρ = −0.531 to −0.757). T₁, low spin‐lock amplitude CWT, and AdT were most responsive to changes in visually intact cartilage adjacent to the lesions. In the context of PTOA, these findings highlight the potential of T₁, CWT, and AdT in evaluation of compositional and structural changes in cartilage.

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Series: Journal of orthopaedic research
ISSN: 0736-0266
ISSN-E: 1554-527X
ISSN-L: 0736-0266
Volume: 39
Issue: 1
Pages: 63 - 73
DOI: 10.1002/jor.24780
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Funding: Support from Jane and Aatos Erkko Foundation, the Academy of Finland (grants #285909, #293970, #319440, and #297033), the Dutch Arthritis Foundation (grants LLP‐12 and LLP‐22), and European Community's Seventh Framework Programme (FP7/2007– 2013) under grant agreement 309962 (HydroZONES) is gratefully acknowledged. Funding sources had no role in the study or its design.
Academy of Finland Grant Number: 297033
Detailed Information: 297033 (Academy of Finland Funding decision)
Copyright information: © 2020 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.