University of Oulu

Peltola, E, Hannula, P, Huhtala, H, et al. Long‐term health‐related quality of life in persons diagnosed with an insulinoma in Finland 1980‐2010. Clin Endocrinol (Oxf) 2021; 94: 250– 257.

Long‐term health‐related quality of life in persons diagnosed with an insulinoma in Finland 1980‐2010

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Author: Peltola, Elina1,2; Hannula, Päivi1,3; Huhtala, Heini4;
Organizations: 1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
2Division of Internal Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland
3Endocrinology, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
4Faculty of Social Sciences, Tampere University, Tampere, Finland
5Department of Public Health, University of Helsinki, Helsinki, Finland
6Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
7Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
8Endocrinology, Abdominal Center, University of Helsinki, Helsinki, Finland
9Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
10Endocrinology, Department of Internal Medicine, Turku University Hospital, Turku, Finland
11Faculty of Medicine, University of Turku, Turku, Finland
12Department of Medicine, Kuopio University Hospital, Kuopio, Finland
13Faculty of Medicine, University of Oulu, Oulu, Finland
14Endocrinology, Department of Medicine, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-02-23


Objective: Insulinomas are rare pancreatic neoplasms, which can usually be cured by surgery. As the diagnostic delay is often long and the prolonged hyperinsulinemia may have long‐term effects on health and the quality of life, we studied the long‐term health‐related quality of life (HRQoL) in insulinoma patients.

Design, patients and measurements: The HRQoL of adults diagnosed with an insulinoma in Finland in 1980‐2010 was studied with the 15D instrument, and the results were compared to those of an age‐ and gender‐matched sample of the general population. The minimum clinically important difference in the total 15D score has been defined as ±0.015. The clinical characteristics, details of insulinoma diagnosis and treatment, and the current health status of the subjects were examined to specify the possible determinants of long‐term HRQoL.

Results: Thirty‐eight insulinoma patients participated in the HRQoL survey (response rate 75%). All had undergone surgery with a curative aim, a median of 13 (min 7, max 34) years before the survey. The insulinoma patients had a clinically importantly and statistically significantly better mean 15D score compared with the controls (0.930 ± 0.072 vs 0.903 ± 0.039, P = .046) and were significantly better off regarding mobility, usual activities and eating. Among the insulinoma patients, younger age at the time of survey, higher level of education and smaller number of chronic diseases were associated with better overall HRQoL.

Conclusions: In the long term, the overall HRQoL of insulinoma patients is slightly better than that of the general population.

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Series: Clinical endocrinology
ISSN: 0300-0664
ISSN-E: 1365-2265
ISSN-L: 0300-0664
Volume: 94
Issue: 2
Pages: 250 - 257
DOI: 10.1111/cen.14336
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This work was financially supported by the Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital (9U012, 5900/3225; EP, PJ), the Medical Research Fund of Seinäjoki Central Hospital (1717/6043, 1717/6080; EP, PJ), the Helsinki University Hospital Research Funds (TYH2019254; CS‐J) and Finska Läkaresällskapet (not numbered; CS‐J).
Copyright information: © 2020 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.