University of Oulu

Jarockyte, Greta; Karabanovas, Vitalijus; Rotomskis, Ricardas; Mobasheri, Ali. 2020. "Multiplexed Nanobiosensors: Current Trends in Early Diagnostics" Sensors 20, no. 23: 6890.

Multiplexed nanobiosensors : current trends in early diagnostics

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Author: Jarockyte, Greta1,2; Karabanovas, Vitalijus1,2; Rotomskis, Ricardas2;
Organizations: 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania
2Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, LT-08406 Vilnius, Lithuania
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014 Oulu, Finland
4Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.9 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2020
Publish Date: 2021-03-01


The ever-growing demand for fast, cheap, and reliable diagnostic tools for personalised medicine is encouraging scientists to improve existing technology platforms and to create new methods for the detection and quantification of biomarkers of clinical significance. Simultaneous detection of multiple analytes allows more accurate assessment of changes in biomarker expression and offers the possibility of disease diagnosis at the earliest stages. The concept of multiplexing, where multiple analytes can be detected in a single sample, can be tackled using several types of nanomaterial-based biosensors. Quantum dots are widely used photoluminescent nanoparticles and represent one of the most frequent choices for different multiplex systems. However, nanoparticles that incorporate gold, silver, and rare earth metals with their unique optical properties are an emerging perspective in the multiplexing field. In this review, we summarise progress in various nanoparticle applications for multiplexed biomarkers.

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Series: Sensors
ISSN: 1424-8220
ISSN-E: 1424-8220
ISSN-L: 1424-8220
Volume: 20
Issue: 23
Article number: 6890
DOI: 10.3390/s20236890
Type of Publication: A1 Journal article – refereed
Field of Science: 318 Medical biotechnology
Funding: This research was funded by the European Regional Development Fund through the Research Council of Lithuania according to the Programme Attracting Foreign Researchers for Research Implementation, Grant No. 01.2.2-LMT-K-718–02-0022.
Copyright information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (