University of Oulu

Thomas Kietzmann. Antioxidants & Redox Signaling. Jan 2019. 1-4.

Cellular redox compartments

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Author: Kietzmann, Thomas1
Organizations: 1Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.1 MB)
Persistent link:
Language: English
Published: Mary Ann Liebert, 2018
Publish Date: 2021-03-03


Although initially considered as harmful, reactive oxygen species (ROS) are now also recognized as important signaling molecules affecting various cellular processes. For example, they contribute to the response to hormones, growth factors, or hypoxia, and defense reactions against mechanical or chemical stress. Therefore, different ROS-generating, ROS-utilizing, and ROS-degrading systems in different intracellular compartments play an important role. On the one hand, this leads to a functional specialization wherein proteins, which participate in a specific ROS-regulated pathway in one compartment, may have another ROS-unrelated specific function in another compartment. On the other hand, this also adds a layer of protection by keeping unwanted side reactions to a minimum. Accordingly, the intracellular communication between different cellular compartments is an important mechanism to achieve proper responses and adaptations at the cellular level.

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Series: Antioxidants & redox signaling
ISSN: 1523-0864
ISSN-E: 1557-7716
ISSN-L: 1523-0864
Volume: 30
Issue: 1
Pages: 1 - 4
DOI: 10.1089/ars.2018.7661
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
3111 Biomedicine
3122 Cancers
Funding: The work in the author`s laboratory is supported by funds from the Finnish Academy of Science (SA296027), the Jane and Aatos Erkko Foundation, Biocenter Oulu, and the University of Oulu.
Copyright information: © 2018, Mary Ann Liebert, Inc., publishers.