University of Oulu

Oleksii Sieryi, Alexey Popov, Vyacheslav Kalchenko, Alexander Bykov, and Igor Meglinski "Tissue-mimicking phantoms for biomedical applications", Proc. SPIE 11363, Tissue Optics and Photonics, 1136312 (12 May 2020);

Tissue-mimicking phantoms for biomedical applications

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Author: Sieryi, Oleksii1; Popov, Alexey2; Kalchenko, Vyacheslav3;
Organizations: 1Opto-Electronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
2VTT Technical Research Centre of Finland, Oulu, Finland
3Weizmann Institute of Science, Israel
4Aston Institute of Materials Research, School of Engineering and Applied Science, Aston University, Birmingham, UK
5School of Life and Health Sciences, Aston University, Birmingham, UK
6Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia
7Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University “MEPhI”, Moscow, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: SPIE, 2020
Publish Date: 2021-03-04


Emerging biomedical instrumentation for imaging and diagnostics requires tissue-mimicking phantoms with optical properties close to those of real biological tissues. Many such tissues and organs consist of several layers with different physical properties, e.g. the head includes the brain, skull, and skin, which in turn also comprise several layers. Structure, optical and mechanical properties depend on the purpose of phantoms and studied materials and technologies. In this paper, we present both plain single-, multi-layered phantoms, and complex opto-mechanical phantoms that imitate parts of the body, in particular, the head. We describe the procedure, materials, internal structure, and tuning of the optical properties of two different phantom manufacturing methods as well as show examples of tissue-mimicking phantoms for different biomedical applications.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
ISBN Print: 978-1-5106-3498-5
Article number: 1136312
DOI: 10.1117/12.2560174
Host publication: Tissue Optics and Photonics 2020
Host publication editor: Tuchin, V. V.
Blondel, W. C. P. M.
Zalevsky, Z.
Conference: SPIE Photonics Europe
Type of Publication: A4 Article in conference proceedings
Field of Science: 213 Electronic, automation and communications engineering, electronics
Funding: This project has received funding from the ATTRACT project funded by the EC under Grant Agreement 777222 and partially by Academy of Finland (grant: 325097, 314369). IM also acknowledges partial support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), Russian Science Foundation (Project 19-72-30012) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program.
Academy of Finland Grant Number: 325097
Detailed Information: 325097 (Academy of Finland Funding decision)
314369 (Academy of Finland Funding decision)
Copyright information: © (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only. Self-archived here with the kind permission of the publisher.