Ali J. Masud, Alexander J. Kastaniotis, M. Tanvir Rahman, Kaija J. Autio, J. Kalervo Hiltunen, Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1866, Issue 12, 2019, 118540, ISSN 0167-4889, https://doi.org/10.1016/j.bbamcr.2019.118540
Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function
|Author:||Masud, Ali J.1; Kastaniotis, Alexander J.1; Rahman, M. Tanvir1;|
1Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 10.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202103046511
|Publish Date:|| 2021-03-04
Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS intermediates to the enzymes responsible for the acyl chain elongation process. Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes. Moreover, octanoyl-ACP provides the C8 backbone for endogenous lipoic acid synthesis. Accumulating evidence suggests that mtFAS-generated acyl-ACPs act as signaling molecules in an intramitochondrial metabolic state sensing circuit, coordinating mitochondrial acetyl-CoA levels with mitochondrial respiration, Fe-S cluster biogenesis and protein lipoylation.
Biochimica et biophysica acta. Molecular cell research
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
1182 Biochemistry, cell and molecular biology
Our original research work was supported by grants from the Sigrid Jusélius Foundation and the Academy of Finland.
© 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license by http://creativecommons.org/licenses/by-nc-nd/4.0/.