University of Oulu

Ali J. Masud, Alexander J. Kastaniotis, M. Tanvir Rahman, Kaija J. Autio, J. Kalervo Hiltunen, Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1866, Issue 12, 2019, 118540, ISSN 0167-4889,

Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function

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Author: Masud, Ali J.1; Kastaniotis, Alexander J.1; Rahman, M. Tanvir1;
Organizations: 1Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 10.2 MB)
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Language: English
Published: Elsevier, 2019
Publish Date: 2021-03-04


Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS intermediates to the enzymes responsible for the acyl chain elongation process. Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes. Moreover, octanoyl-ACP provides the C8 backbone for endogenous lipoic acid synthesis. Accumulating evidence suggests that mtFAS-generated acyl-ACPs act as signaling molecules in an intramitochondrial metabolic state sensing circuit, coordinating mitochondrial acetyl-CoA levels with mitochondrial respiration, Fe-S cluster biogenesis and protein lipoylation.

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Series: Biochimica et biophysica acta. Molecular cell research
ISSN: 0167-4889
ISSN-E: 1879-2596
ISSN-L: 0167-4889
Volume: 1866
Issue: 12
Article number: 118540
DOI: 10.1016/j.bbamcr.2019.118540
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: Our original research work was supported by grants from the Sigrid Jusélius Foundation and the Academy of Finland.
Copyright information: © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license by