University of Oulu

FARRAHI, VAHID; KANGAS, MAARIT; WALMSLEY, ROSEMARY; NIEMELÄ, MAISA; KIVINIEMI, ANTTI; PUUKKA, KATRI; COLLINGS, PAUL J.; KORPELAINEN, RAIJA; JÄMSÄ, TIMO Compositional Associations of Sleep and Activities within the 24-h Cycle with Cardiometabolic Health Markers in Adults, Medicine & Science in Sports & Exercise: February 2021 - Volume 53 - Issue 2 - p 324-332 doi: 10.1249/MSS.0000000000002481

Compositional associations of sleep and activities within the 24-h cycle with cardiometabolic health markers in adults

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Author: Farrahi, Vahid1; Kangas, Maarit1,2; Walmsley, Rosemary3;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, FINLAND
2Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, FINLAND
3Big Data Institute, University of Oxford, Oxford, UNITED KINGDOM
4Research Unit of Internal Medicine, University of Oulu, Oulu, FINLAND
5NordLab Oulu, Medical Research Center Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, FINLAND
6Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UNITED KINGDOM
7Department of Health Sciences, University of York, York, UNITED KINGDOM
8Center for Life Course Health Research,University of Oulu, Oulu, FINLAND
9Oulu Deaconess Institute Foundation, Department of Sports and Exercise Medicine, FINLAND
10Diagnostic Radiology, Oulu University Hospital, Oulu, FINLAND
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202103096841
Language: English
Published: Wolters Kluwer, 2021
Publish Date: 2021-03-09
Description:

Abstract

Purpose: This study aimed to examine how compositions of 24-h time use and time reallocations between movement behaviors are associated with cardiometabolic health in a population-based sample of middle-age Finnish adults.

Methods: Participants were 3443 adults 46 yr of age from the Northern Finland Birth Cohort 1966 study. Participants wore a hip-worn accelerometer for 14 d from which time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA) were determined. These data were combined with self-reported sleep to obtain the 24-h time-use composition. Cardiometabolic outcomes included adiposity markers, blood lipid levels, and markers of glucose control and insulin sensitivity. Multivariable-adjusted regression analysis, using a compositional data analysis approach based on isometric log-ratio transformation, was used to examine associations between movement behaviors with cardiometabolic outcomes.

Results: More daily time in MVPA and LPA, relative to other movement behaviors, was consistently favorably associated with all cardiometabolic outcomes. For example, relative to time spent in other behaviors, 30 min·d−1 more MVPA and LPA were both associated with lower 2-h post–glucose load insulin level (−11.8% and −2.7%, respectively). Relative to other movement behaviors, more daily time in SB was adversely associated with adiposity measures, lipid levels, and markers of insulin sensitivity, and more daily time asleep was adversely associated with adiposity measures, blood lipid, fasting plasma glucose, and 2-h insulin. For example, 60 min·d−1 more SB and sleep relative to the remaining behaviors were both associated with higher 2-h insulin (3.5% and 5.7%, respectively).

Conclusions: Altering daily movement behavior compositions to incorporate more MVPA at the expense of any other movement behavior, or more LPA at the expense of SB or sleep, could help to improve cardiometabolic health in midadulthood.

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Series: Medicine & science in sports & exercise
ISSN: 0195-9131
ISSN-E: 1530-0315
ISSN-L: 0195-9131
Volume: 53
Issue: 2
Pages: 324 - 332
DOI: 10.1249/MSS.0000000000002481
OADOI: https://oadoi.org/10.1249/MSS.0000000000002481
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
Subjects:
Funding: NFBC1966 received financial support from the University of Oulu (grant no. 24000692), the Oulu University Hospital (grant no. 24301140), and the European Regional Development Fund (grant no. 539/2010 A31592). The present study has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska–Curie grant agreement no. 713645, the Ministry of Education and Culture in Finland (grant nos. OKM/86/626/2014, OKM/43/626/2015, OKM/17/626/2016, and OKM/54/626/2019), and the Northern Ostrobothnia Hospital District. These funders also supported VF’s placement at Bradford Institute for Health Research where the data analysis was performed. PJC is funded by a British Heart Foundation (BHF) Immediate Postdoctoral Basic Science Research Fellowship (FS/17/37/32937). RW is supported by a Medical Research Council Industrial Strategy Studentship (grant no. MR/S502509/1). AMK is funded by the Finnish Foundation for Cardiovascular Research (Helsinki, Finland). The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The authors declare no conflicts of interest. The results of the present study do not constitute endorsement by the American College of Sports Medicine.
Copyright information: © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.on behalf of the American College of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
  https://creativecommons.org/licenses/by-nc-nd/4.0/