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Hallikainen, J., Keränen, S., Savolainen, J. et al. Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms. Neurosurg Rev 44, 239–247 (2021). https://doi.org/10.1007/s10143-020-01253-y

Role of oral pathogens in the pathogenesis of intracranial aneurysm : review of existing evidence and potential mechanisms

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Author: Hallikainen, Joona1,2,3,4; Keränen, Sara3; Savolainen, Jarno1,2;
Organizations: 1Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
2Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland
3Hemorrhagic Brain Pathology Research Group, Kuopio University Hospital, Kuopio, Finland
4Hemorrhagic Brain Pathology Research Group, Tampere University Hospital and University of Tampere, Tampere, Finland
5Department of Biomedicine, University of Eastern Finland, Kuopio, Finland
6Public Health Evaluation and Projection Unit, National Institute for Health and Welfare, Helsinki, Finland
7Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
8Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
9Department of Pathology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
10Department of Neurosurgery, Tampere University Hospital and University of Tampere, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202103096861
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-03-09
Description:

Abstract

Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.

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Series: Neurosurgical review
ISSN: 0344-5607
ISSN-E: 1437-2320
ISSN-L: 0344-5607
Volume: 44
Issue: 1
Pages: 239 - 247
DOI: 10.1007/s10143-020-01253-y
OADOI: https://oadoi.org/10.1007/s10143-020-01253-y
Type of Publication: A2 Review article in a scientific journal
Field of Science: 313 Dentistry
Subjects:
Intracranial aneurysm
Oral diseases
Pathogens
Periodontitis
Subarachnoidal hemorrhage
Article
Funding: Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital.
Copyright information: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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