Hallikainen, J., Keränen, S., Savolainen, J. et al. Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms. Neurosurg Rev 44, 239–247 (2021). https://doi.org/10.1007/s10143-020-01253-y
Role of oral pathogens in the pathogenesis of intracranial aneurysm : review of existing evidence and potential mechanisms
|Author:||Hallikainen, Joona1,2,3,4; Keränen, Sara3; Savolainen, Jarno1,2;|
1Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
2Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland
3Hemorrhagic Brain Pathology Research Group, Kuopio University Hospital, Kuopio, Finland
4Hemorrhagic Brain Pathology Research Group, Tampere University Hospital and University of Tampere, Tampere, Finland
5Department of Biomedicine, University of Eastern Finland, Kuopio, Finland
6Public Health Evaluation and Projection Unit, National Institute for Health and Welfare, Helsinki, Finland
7Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
8Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
9Department of Pathology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
10Department of Neurosurgery, Tampere University Hospital and University of Tampere, Tampere, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe202103096861
|Publish Date:|| 2021-03-09
Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.
|Pages:||239 - 247|
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital.
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