University of Oulu

Jauhiainen, R., Jauhiainen, M., Vangipurapu, J., Kuulasmaa, T., Ala‐Korpela, M., Laakso, M., and Kuusisto, J. (2021) Novel biomarkers associated with incident heart failure in 10 106 Finnish men. ESC Heart Failure, 8: 605– 614.

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Saved in:
Author: Jauhiainen, Raimo1; Jauhiainen, Matti1; Vangipurapu, Jagadish1;
Organizations: 1Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland
2Institute of Biomedicine, Bioinformatics Center, University of Eastern Finland, Kuopio, Finland
3NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
4Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland
5Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, FIN‐70029 KYS Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-03-10


Aims: There are only a few studies on novel biomarkers for incident heart failure (HF). We investigated the association of multiple circulating biomarkers with incident HF in a large prospective population‐based study.

Methods and results: Conventional risk factors and inflammatory biomarkers were measured, and systemic metabolic measures determined by a high‐throughput serum nuclear magnetic resonance platform in a population‐based Metabolic Syndrome in Men study including 10 106 Finnish men without HF at baseline. During an 8.8 year follow‐up, 172 (1.7%) participants developed HF. Adiponectin, high‐sensitivity C‐reactive protein (hs‐CRP), glycoprotein acetyls, alanine, phenylalanine, glycerol, and pyruvate were associated with incident HF in unadjusted Cox regression analyses, in addition to age, systolic blood pressure, body mass index (BMI), waist circumference, fasting plasma glucose and insulin, haemoglobin A1c (HbA1c), and urinary albumin excretion rate (UAER). After adjustment for age, BMI, diabetes, and statin medication, only adiponectin [hazard ratio (HR) 1.18 (1.10–1.26, P = 4.1E‐08)], pyruvate [HR 1.38 (1.28–1.50, P = 8.2E‐05)], and UAER [HR 1.15 (1.11—1.18, P = 7.8E‐06)] remained statistically significant. In principal component analysis of biomarkers associated with HF in univariate Cox regression analysis, we identified six components, explaining 61.7% of total variance. Four principal components, one with significant loadings on waist, BMI, fasting plasma insulin, interleukin 1 receptor antagonist, and hs‐CRP; another on pyruvate, glycoprotein acetyls, alanine, glycerol and HbA1c; third on age and glomerular filtration rate; and fourth on systolic blood pressure, UAER, and adiponectin, significantly associated with incident HF.

Conclusions: Several novel metabolic and inflammatory biomarkers were associated with incident HF, suggesting early activation of respective pathways in the pathogenesis of HF.

see all

Series: ESC heart failure
ISSN: 2055-5822
ISSN-E: 2055-5822
ISSN-L: 2055-5822
Volume: 8
Issue: 1
DOI: 10.1002/ehf2.13132
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Funding: This work was supported by the Kuopio University Hospital and the Finnish Heart Research Foundation (grants to Johanna Kuusisto) and Academy of Finland (grants to Markku Laakso). Mika Ala‐Korpela is supported by a research grant from the Sigrid Juselius Foundation, Finland.
Copyright information: © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.