University of Oulu

Parkkila, K., Valtonen, R.I.P., Hiltunen, L. et al. The effects of submaximal exercise and cold exposure on blood coagulation parameters in coronary artery disease patients. BMC Cardiovasc Disord 21, 93 (2021).

The effects of submaximal exercise and cold exposure on blood coagulation parameters in coronary artery disease patients

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Author: Parkkila, Karri1; Valtonen, Rasmus I. P.1,2; Hiltunen, Leena3;
Organizations: 1Center for Environmental and Respiratory Health Research (CERH), University of Oulu, P.O. Box 5000, 90014, Oulu, Finland
2Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland
3Present address: Hemostasis and Platelet Laboratory, Fimlab Laboratoriot Oy Ltd, Vantaa, Finland
4Centria University of Applied Sciences, Kokkola, Finland
5Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Springer Nature, 2021
Publish Date: 2021-04-16


Background: Both exercise and cold exposure increase blood coagulation potential but their combined effects are not known. The purpose of the present study was to assess blood coagulation factors in response to submaximal exercise in the cold environment among patients with stable coronary artery disease (CAD).

Methods: Sixteen men (61.1 ± 7.1 years) with stable CAD participated in three 30-min experimental conditions (seated rest in − 15 °C and exercise in both + 22 °C and − 15 °C) in random order. The employed exercise consisted of brisk walking (66–69% of maximal heart rate). Factor VII (FVII), fibrinogen, D-dimer and von Willebrand factor (vWF) were analyzed from blood samples obtained before, immediately and one hour after each experiment.

Results: On average, FVII activity (95% confidence interval, CI) was 123 (108–143) %, 123 (106–140) %, 121 (103–139) % (baseline, recovery 1, recovery 2), fibrinogen concentration (95% CI) 3.81 (3.49–4.12) g/l, 3.71 (3.34–4.08) g/l, 3.65 (3.26–4.05) g/l, D-dimer concentration (95% CI) 0.42 (0.28–0.56) µg/ml, 0.42 (0.29-.55) µg/ml and 0.39 (0.29–0.49) µg/ml, and vWF activity (95% CI) 184 (135–232) %, 170 (128–212) % and 173 (129–217) % after exercise in the cold. Average FVII activity varied from 122 to 123%, fibrinogen concentration from 3.71 to 3.75 g/l, D-dimer concentration from 0.35 to 0.51 µg/ml and von Willebrand factor activity from 168 to 175% immediately after each three experimental condition.

Conclusions: Our findings suggest that submaximal lower body exercise carried out in a cold environment does not significantly affect blood coagulation parameters among patients with stable CAD.

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Series: BMC cardiovascular disorders
ISSN: 1471-2261
ISSN-E: 1471-2261
ISSN-L: 1471-2261
Volume: 21
Article number: 93
DOI: 10.1186/s12872-021-01907-9
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: The study was funded through grants from the Finnish Ministry of Education and Culture (TI), Juho Vainio Foundation (RV), and Yrjö Jahnsson Foundation (TI, HH).
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