University of Oulu

Jarkko S. Heiskanen, Jussi A. Hernesniemi, Saku Ruohonen, Nina Hutri-Kähönen, Mika Kähönen, Eero Jokinen, Päivi Tossavainen, Merja Kallio, Tomi Laitinen, Terho Lehtimäki, Jorma Viikari, Markus Juonala, Jaakko Nevalainen & Olli T. Raitakari (2021) Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood – the Cardiovascular Risk in Young Finns Study, Annals of Medicine, 53:1, 160-168, DOI: 10.1080/07853890.2020.1849785

Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood : the Cardiovascular Risk in Young Finns Study

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Author: Heiskanen, Jarkko S.1,2; Hernesniemi, Jussi A.3; Ruohonen, Saku1,2,4;
Organizations: 1Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
2Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
3Tays Heart Hospital, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
4Orion Pharma, Espoo, Finland
5Department of Paediatrics Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
6Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
7Department of Paediatric Cardiology, HUS New Children’s Hospital, University of Helsinki, Helsinki, Finland
8Department of Pediatrics, PEDEGO Research Unit and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
9Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Finland
10Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
11Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
12Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland
13Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021041910839
Language: English
Published: Informa, 2021
Publish Date: 2021-04-19
Description:

Abstract

Background: Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood.

Methods: We used longitudinal data from a 31-year follow-up to examine the associations between early-life (between ages 6–18) BMI and SPB on LVM in an adult population (N = 1864, aged 34–49). The burden of early-life BMI and SBP was defined as area under the curve.

Results: After accounting for contemporary adult determinants of LVM, early-life BMI burden associated significantly with LVM (3.61 g/SD increase in early-life BMI; [1.94 − 5.28], p < 0.001). Overweight in early-life (age- and sex-specific BMI values corresponding to adult BMI > 25 kg/m²) associated with 4.7% (2.5–6.9%, p < 0.0001) higher LVM regardless of BMI status in adulthood. Overweight in early-life combined with obesity in adulthood (BMI > 30kg/m²) resulted in a 21% (17.3–32.9%, p < 0.0001) increase in LVM. Higher early-life BMI was associated with a risk of developing eccentric hypertrophy. The burden of early-life SPB was not associated with adult LVM or left ventricular remodeling.

Conclusions: High BMI in early-life confers a sustained effect on LVM and the risk for eccentric hypertrophy independently of adulthood risk factors.

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Series: Annals of medicine
ISSN: 0785-3890
ISSN-E: 1365-2060
ISSN-L: 0785-3890
Volume: 53
Issue: 1
Pages: 160 - 168
DOI: 10.1080/07853890.2020.1849785
OADOI: https://oadoi.org/10.1080/07853890.2020.1849785
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: The Young Finns Study has been financially supported by the Academy of Finland [grants 255381, 256474, 283115, 302382, 319060, 320297, 314389 (TERVA), 322098, 286284, 134309 (EYE), 126925, 121584, 124282, 129378 (SALVE), 117797 (GENDI), 273971 (TULOS) and 141071 (SKIDI)]; the Ministry of Education and Culture, Finland; the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospital grants; Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Päivikki and Sakari Sohlberg Foundation; Finnish Sport Institute Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 [grant 755320 for TAXINOMISIS]; European Research Council [grant 742927 for MULTIEPIGEN project]; and Tampere University Hospital Supporting Foundation. All authors have approved the final article and take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Academy of Finland Grant Number: 322098
Detailed Information: 322098 (Academy of Finland Funding decision)
Copyright information: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  https://creativecommons.org/licenses/by/4.0/