Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Kati Heinonen, Jari Lahti, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Hannele Laivuori, Katri Raikkonen, Maternal antenatal stress and mental and behavioral disorders in their children, Journal of Affective Disorders, Volume 278, 2021, Pages 57-65, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2020.09.063
Maternal antenatal stress and mental and behavioral disorders in their children
|Author:||Tuovinen, Soile1; Lahti-Pulkkinen, Marius1; Girchenko, Polina1;|
1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
2Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
3Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
5National Institute for Health and Welfare, Helsinki, Finland
6PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
7Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
8Department of Clinical and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway
9Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
10Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
11Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland
|Online Access:||PDF Full Text (PDF, 1.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021041910847
|Publish Date:|| 2021-04-19
Background: Maternal antenatal stress, including symptoms of depression, anxiety and perceived stress, is associated with mental and behavioral problems in children. Whether it is associated with child mental and behavioral disorders remains uncertain. We examined if maternal antenatal symptoms of depression, anxiety and perceived stress were associated with mental and behavioral disorders in their children, if the associations varied according to gestational week, stress type, fluctuating or consistently high symptoms, and if they were driven by maternal or paternal lifetime mood or anxiety disorders.
Methods: 3365 mothers participating in the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiologic Studies Depression Scale, the State Anxiety Inventory and the Perceived Stress Scale up to 14 times throughout pregnancy. The Care Register for Health Care provided data on mental and behavioral (including neurodevelopmental) disorders for their children from birth (11/07/2006–07/24/2010) until 12/31/2016 and for parental lifetime mood and anxiety disorders until 12/31/2016.
Results: The hazard of any childhood mental and behavioral disorder (HR=1.91, 95% CI: 1.39–2.51) was significantly higher for children whose mothers reported consistently high in comparison to consistently low levels of all types of stress throughout pregnancy. The associations remained significant when adjusted for maternal and paternal lifetime mood and anxiety disorders (and their comorbidity and timing and mood disorder type).
Conclusions: Maternal antenatal stress is associated with higher risk of childhood mental and behavioral disorders. Efforts to reduce maternal antenatal stress should be given a high priority to improve child mental health.
Journal of affective disorders
|Pages:||57 - 65|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
The PREDO study is funded by the Academy of Finland, European Union's Horizon 2020 Award SC1–2016-RTD-733280 for Research on European Children and Adults Born Preterm (RECAP), European Commission Dynamics of Inequality Across the Life- course: structures and processes (DIAL) No 724363 for PremLife, EVO (a special state subsidy for health science research), University of Helsinki Research Funds, Signe and Ane Gyllenberg Foundation, Diabetes Research Foundation, Emil Aaltonen Foundation, Finnish Medical Foundation, Foundation for Pediatric Research, Foundation for Cardiovascular Research, Jane and Aatos Erkko Foundation, Novo Nordisk Foundation, Päivikki and Sakari Sohlberg Foundation, Sigrid Juselius Foundation, Sir Jules Thorn Charitable Trust and British Heart Foundation (RE/18/5/34216).
© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).