University of Oulu

Kiiskilä, J., Jokelainen, J., Kytövuori, L. et al. Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts. BMC Genomics 22, 75 (2021).

Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts

Saved in:
Author: Kiiskilä, Jukka1,2; Jokelainen, Jari3,4; Kytövuori, Laura1,2;
Organizations: 1Research Unit of Clinical Neuroscience, Neurology, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland
2Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland
3Center for Life Course Health Research, University of Oulu, Oulu, Finland
4Unit of General Practice, Oulu University Hospital, Oulu, Finland
5Rovaniemi Health Center, Rovaniemi, Finland
6Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
7Healthcare and Social Services of Selänne, Pyhäjärvi, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link:
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-04-22


Background: We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.

Results: Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001).

Conclusions: These results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.

see all

Series: BMC genomics
ISSN: 1471-2164
ISSN-E: 1471-2164
ISSN-L: 1471-2164
Volume: 22
Issue: 1
Article number: 75
DOI: 10.1186/s12864-021-07383-x
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Funding: This study was funded by grants from the Sigrid Juselius Foundation. The funding body did not have any role in the design of the study, collection, analysis or interpretation of the data or in writing of the manuscript.
Copyright information: © The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.