Kiiskilä, J., Jokelainen, J., Kytövuori, L. et al. Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts. BMC Genomics 22, 75 (2021). https://doi.org/10.1186/s12864-021-07383-x
Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts
|Author:||Kiiskilä, Jukka1,2; Jokelainen, Jari3,4; Kytövuori, Laura1,2;|
1Research Unit of Clinical Neuroscience, Neurology, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland
2Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland
3Center for Life Course Health Research, University of Oulu, Oulu, Finland
4Unit of General Practice, Oulu University Hospital, Oulu, Finland
5Rovaniemi Health Center, Rovaniemi, Finland
6Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
7Healthcare and Social Services of Selänne, Pyhäjärvi, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021042211335
|Publish Date:|| 2021-04-22
Background: We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.
Results: Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001).
Conclusions: These results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This study was funded by grants from the Sigrid Juselius Foundation. The funding body did not have any role in the design of the study, collection, analysis or interpretation of the data or in writing of the manuscript.
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