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Oikarinen M, Puustinen L, Lehtonen J, Hakola L, Simell S, Toppari J, Ilonen J, Veijola R, Virtanen SM, Knip M and Hyöty H (2021) Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front. Immunol. 11:604529. doi: 10.3389/fimmu.2020.604529

Enterovirus infections are associated with the development of celiac disease in a birth cohort study

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Author: Oikarinen, Maarit1; Puustinen, Leena1; Lehtonen, Jussi1;
Organizations: 1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
2Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland
3Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland
4Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland
5Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
6Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
7PEDEGO Research Unit, Medical Research Centre, Department of Paediatrics, University of Oulu, Oulu, Finland
8Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
9Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
10Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland
11Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
12Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
13Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021042611928
Language: English
Published: Frontiers Media, 2021
Publish Date: 2021-04-26
Description:

Abstract

Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.

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Series: Frontiers in immunology
ISSN: 1664-3224
ISSN-E: 1664-3224
ISSN-L: 1664-3224
Volume: 11
Article number: 604529
DOI: 10.3389/fimmu.2020.604529
OADOI: https://oadoi.org/10.3389/fimmu.2020.604529
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Finnish Diabetes Prediction and Prevention study
celiac disease
conditional logistic regression
enterovirus
enzyme immunoassay (EIA)
tissue transglutaminase autoantibodies
Article
Funding: This study was supported by grants from the Finnish Technology Agency TEKES (currently Business Finland), Academy of Finland (276475, 308066), Reino Lahtikari Foundation, Sigrid Juselius Foundation and the Competitive State Research Financing of the Expert Responsibility area of Tampere, Turku and Oulu University Hospitals [X50040, 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L042, 9L117, 9M036, 9M114, 9N086, 9P057, 9R055, 9S074, 9T072]. The study sponsors had no role in the design, analysis or writing of this article.
Copyright information: © 2021 Oikarinen, Puustinen, Lehtonen, Hakola, Simell, Toppari, Ilonen, Veijola, Virtanen, Knip and Hyöty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  https://creativecommons.org/licenses/by/4.0/