Enterovirus infections are associated with the development of celiac disease in a birth cohort study
Oikarinen, Maarit; Puustinen, Leena; Lehtonen, Jussi; Hakola, Leena; Simell, Satu; Toppari, Jorma; Ilonen, Jorma; Veijola, Riitta; Virtanen, Suvi M.; Knip, Mikae; Hyöty, Heikki (2021-02-02)
Oikarinen M, Puustinen L, Lehtonen J, Hakola L, Simell S, Toppari J, Ilonen J, Veijola R, Virtanen SM, Knip M and Hyöty H (2021) Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study. Front. Immunol. 11:604529. doi: 10.3389/fimmu.2020.604529
© 2021 Oikarinen, Puustinen, Lehtonen, Hakola, Simell, Toppari, Ilonen, Veijola, Virtanen, Knip and Hyöty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2021042611928
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Abstract
Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
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