University of Oulu

Perhomaa, M.; Pokka, T.; Korhonen, L.; Kyrö, A.; Niinimäki, J.; Serlo, W.; Sinikumpu, J.-J. Randomized Controlled Trial of the Clinical Recovery and Biodegradation of Polylactide-co-glycolide Implants Used in the Intramedullary Nailing of Children’s Forearm Shaft Fractures with at Least Four Years of Follow-Up. J. Clin. Med. 2021, 10, 995.

Randomized controlled trial of the clinical recovery and biodegradation of polylactide-co-glycolide implants used in the intramedullary nailing of children’s forearm shaft fractures with at least four years of follow-up

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Author: Perhomaa, Marja1; Pokka, Tytti2; Korhonen, Linda2;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology (MIPT), Department of Diagnostic Imaging, Oulu University Hospital, PoB 50, 90029 Oulu, Finland
2Department of Children and Adolescents/Pediatric Surgery and Orthopedics, PEDEGO Research Center, Oulu University Hospital, 90029 Oulu, Finland
3Department of Children, Pediatric Surgery, Päijät-Häme Central Hospital, FIN-Keskussairaalankatu 7, 15850 Lahti, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2021
Publish Date: 2021-04-30


The preferred surgical fixation of forearm shaft fractures in children is Elastic Stable Intramedullary Nailing (ESIN). Due to known disadvantageous effects of metal implants, a new surgical method using biodegradable polylactide-co-glycolide (PLGA) intramedullary nails has been developed but its long-term outcomes are unclear. The aim of this study was to compare the long-term outcomes of Biodegradable Intramedullary Nailing (BIN) to ESIN and assess the biodegradation of the study implants via magnetic resonance imaging (MRI). The study population of the prospective, randomized trial consisted of paediatric patients whose forearm shaft fractures were treated with BIN (n = 19) or ESIN (n = 16). Forearm rotation at minimally four years’ follow-up was the main outcome. There was no clinically significant difference in the recovery of the patients treated with the BIN as compared to those treated with the ESIN. More than half of the implants (57.7%, n = 15/26) were completely degraded, and the rest were degraded almost completely. The PLGA intramedullary nails used in the treatment of forearm shaft fractures in this study resulted in good function and anatomy. No unexpected disadvantages were found in the degradation of the implants. However, two implant failures had occurred in three months postoperatively.

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Series: Journal of clinical medicine
ISSN: 2077-0383
ISSN-E: 2077-0383
ISSN-L: 2077-0383
Volume: 10
Issue: 5
Article number: 995
DOI: 10.3390/jcm10050995
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Copyright information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (