University of Oulu

Fedorovich, A.A.; Loktionova, Y.I.; Zharkikh, E.V.; Mikhailova, M.A.; Popova, J.A.; Suvorov, A.V.; Zherebtsov, E.A. Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors. Diagnostics 2021, 11, 436. https://doi.org/10.3390/diagnostics11030436

Body position affects capillary blood flow regulation measured with wearable blood flow sensors

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Author: Fedorovich, Andrey A.1,2; Loktionova, Yulia I.3; Zharkikh, Elena V.3;
Organizations: 1National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Petroverigsky 10, 101990 Moscow, Russia
2Russian Federation State Research Center, Institute of Biomedical Problems of the Russian Academy of Sciences, Khoroshevskoe Highway 76A, 123007 Moscow, Russia
3Orel State University, Komsomolskaya 95, 302026 Orel, Russia
4Optoelectronics and Measurement Techniques, University of Oulu, Erkki Koiso-Kanttilankatu 3, 90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021050729178
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2021
Publish Date: 2021-05-07
Description:

Abstract

In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteers (44 ± 12 years). Wearable laser Doppler flowmetry monitors were fixed at six points on the body: two devices were fixed on the forehead, on the brow; two were on the distal thirds of the right and left forearms; and two were on the distal thirds of the right and left lower legs. The protocol was used to record three body positions on the tilt table for orthostatic test for each volunteer in the following sequence: (a) supine body position; (b) upright body position (+75°); (c) tilted with the feet elevated above the head and the inclination of body axis of 15° (−15°, Trendelenburg position). Skin blood perfusion was recorded for 10 min in each body position, followed by the amplitude–frequency analysis of the registered signals using wavelet decomposition. The measurements were supplemented with the blood pressure and heart rate for every body position analysed. The results identified a statistically significant transformation in microcirculation parameters of the average level of skin blood perfusion and oscillations of amplitudes of neurogenic, myogenic and cardiac sensors caused by the postural changes. In paper, we present the analysis of microcirculation in the skin of the forehead, which for the first time was carried out in various positions of the body. The area is supplied by the internal carotid artery system and can be of particular interest for evaluation of the sufficiency of blood supply for the brain.

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Series: Diagnostics
ISSN: 2075-4418
ISSN-E: 2075-4418
ISSN-L: 2075-4418
Volume: 11
Issue: 3
Article number: 436
DOI: 10.3390/diagnostics11030436
OADOI: https://oadoi.org/10.3390/diagnostics11030436
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
217 Medical engineering
Subjects:
Funding: The reported study was funded by the Russian Foundation for Basic Research (RFBR), grant number 20-08-01153. A. Fedorovich, J. Popova and A. Suvorov were funded in the framework of the research topic 64.1 by the Russian Academy of Science (RAS). E. Zherebtsov acknowledges the funding from the Academy of Finland, grant number 318281.
Copyright information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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