University of Oulu

Anna-Maija Lahti, Juha Huhtakangas, Seppo Juvela, Michaela K. Bode, Sami Tetri, Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage, Epilepsy Research, Volume 172, 2021, 106586, ISSN 0920-1211, https://doi.org/10.1016/j.eplepsyres.2021.106586

Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage

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Author: Lahti, Anna-Maija1; Huhtakangas, Juha1; Juvela, Seppo2;
Organizations: 1Department of Neurology, Oulu University Hospital, Box 25, 90029 OYS, Finland
2Department of Clinical Neurosciences, University of Helsinki, Haartmaninkatu 4, PO Box 22, 00014, Finland
3Department of Diagnostic Radiology, Oulu University Hospital, Box 25, 90029 OYS, Finland
4Department of Neurosurgery, Oulu University Hospital, Box 25, 90029 OYS, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021051029476
Language: English
Published: Elsevier, 2021
Publish Date: 2021-05-10
Description:

Abstract

Objectives: This study aimed to determine whether post-stroke epilepsy (PSE) predicts mortality, and to describe the most prominent causes of death (COD) in a long-term follow-up after primary intracerebral hemorrhage (ICH).

Methods: We followed 3-month survivors of a population-based cohort of primary ICH patients in Northern Ostrobothnia, Finland, for a median of 8.8 years. Mortality and CODs were compared between those who developed PSE and those who did not. PSE was defined according to the ILAE guidelines. CODs were extracted from death certificates (Statistics Finland).

Results: Of 961 patients, 611 survived for 3 months. 409 (66.9%) had died by the end of the follow-up. Pneumonia was the only COD that was significantly more common among the patients with PSE (56% vs. 37% of deaths). In the multivariable models, PSE (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.06–1.87), age (HR 1.07, 95% CI 1.06–1.08), male sex (HR 1.35, 95% CI 1.09–1.67), dependency at 3 months (HR 1.52, 95% CI 1.24–1.88), non-subcortical ICH location (subcortical location HR 0.78, 95% CI 0.61−0.99), diabetes (HR 1.43, 95% CI 1.07–1.90) and cancer (HR 1.45, 95% CI 1.06–1.98) predicted death in the long-term follow-up.

Conclusion: PSE independently predicted higher late morality of ICH in our cohort. Pneumonia-related deaths were more common among the patients with PSE.

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Series: Epilepsy research
ISSN: 0920-1211
ISSN-E: 1872-6844
ISSN-L: 0920-1211
Volume: 172
Article number: 106586
DOI: 10.1016/j.eplepsyres.2021.106586
OADOI: https://oadoi.org/10.1016/j.eplepsyres.2021.106586
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This study was funded by personal grants (Dr. Lahti) from the Orion Research Foundation and the Finnish Epilepsy Association.
Copyright information: © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/