University of Oulu

Thomas Kietzmann, Ville H. Mäkelä, The hypoxia response and nutritional peptides, Peptides, Volume 138, 2021, 170507, ISSN 0196-9781,

The hypoxia response and nutritional peptides

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Author: Kietzmann, Thomas1; Mäkelä, Ville H.1
Organizations: 1University of Oulu, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
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Language: English
Published: Elsevier, 2021
Publish Date: 2021-05-14


Hypoxia controls metabolism at several levels, e.g., via mitochondrial ATP production, glucose uptake and glycolysis. Hence it is likely that hypoxia also affects the action and/or production of many peptide hormones linked to food intake and appetite control. Many of those are produced in the gastrointestinal tract, endocrine pancreas, adipose tissue, and selective areas in the brain which modulate and concert their actions. However, the complexity of the hypoxia response and the links to peptides/hormones involved in food intake and appetite control in the different organs are not well known. This review summarizes the role of the hypoxia response and its effects on major peptides linked to appetite regulation, nutrition and metabolism.

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Series: Peptides
ISSN: 0196-9781
ISSN-E: 1873-5169
ISSN-L: 0196-9781
Volume: 138
Article number: 170507
DOI: 10.1016/j.peptides.2021.170507
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
3111 Biomedicine
Funding: Work in the TK lab was supported by the Academy of FinlandSA296027, the Jane and Aatos Erkko Foundation, the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the University of Oulu, and Biocenter Oulu. Biocenter Oulu is a member of Biocenter Finland.
Academy of Finland Grant Number: 296027
Detailed Information: 296027 (Academy of Finland Funding decision)
Copyright information: © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (