University of Oulu

Martinez, MM, Salami, F, Larsson, HE, et al; The TEDDY Family (TEFA) Study Group. Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA. Endocrinol Diab Metab. 2021; 4:e00198.

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study : TEFA

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Author: Martinez, Maria Månsson1; Salami, Falastin1; Larsson, Helena Elding1;
Organizations: 1Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital, Malmö, Sweden
2Department of Pediatrics, Turku University Hospital, Turku, Finland
3Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Research Centre for Population Health, University of Turku, Turku, Finland
4Department of Pediatrics, PEDEGO Research Unit, MRC Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-05-17


Aim: The aim of the present study was to assess beta cell function based on an oral glucose tolerance test (OGTT) in participants with single islet autoantibody or an intravenous glucose tolerance test (IvGTT) in participants with multiple islet autoantibodies.

Materials and methods: Healthy participants in Sweden and Finland, between 2 and 49.99 years of age previously identified as positive for a single (n = 30) autoantibody to either insulin, glutamic acid decarboxylase, islet antigen‐2, zinc transporter 8 or islet cell antibodies or multiple autoantibodies (n = 46), were included. Participants positive for a single autoantibody underwent a 6‐point OGTT while participants positive for multiple autoantibodies underwent an IvGTT. Glucose, insulin and C‐peptide were measured from OGTT and IvGTT samples.

Results: All participants positive for a single autoantibody had a normal glucose tolerance test with 120 minutes glucose below 7.70 mmol/L and HbA1c values within the normal range (<42 mmol/mol). Insulin responses to the glucose challenge on OGTT ranged between 13.0 and 143 mIU/L after 120 minutes with C‐peptide values between 0.74 and 4.60 nmol/L. In Swedish participants, the first‐phase insulin response (FPIR) on IvGTT was lower in those positive for three or more autoantibodies (n = 13; median 83.0 mIU/L; range 20.0‐343) compared to those with two autoantibodies (n = 15; median 146 mIU/L; range 19.0‐545; P = .0330).

Conclusion: Participants positive for a single autoantibody appeared to have a normal beta cell function. Participants positive for three or more autoantibodies had a lower FPIR as compared to participants with two autoantibodies, supporting the view that their beta cell function had deteriorated.

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Series: Endocrinology, diabetes & metabolism
ISSN: 2398-9238
ISSN-E: 2398-9238
ISSN-L: 2398-9238
Volume: 4
Issue: 2
Article number: e00198
DOI: 10.1002/edm2.198
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: The study was funded by a grant (2‐SRA‐2014‐309‐M‐R) from the Juvenile Diabetes Research Foundation (JDRF), LUDC‐IRC: Swedish Foundation for Strategic Research, Dnr IRC15‐0067 and EXODIAB: Swedish Research Council, Strategic Research Area, Dnr 2009‐1039. Clinical Trials Identifier: NCT02605148.
Copyright information: © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.