University of Oulu

Mellembakken, J. R., Mahmoudan, A., Mørkrid, L., Sundström-Poromaa, I., Morin-Papunen, L., Tapanainen, J. S., Piltonen, T. T., Hirschberg, A. L., Stener-Victorin, E., Vanky, E., Ravn, P., Jensen, R. C., Andersen, M. S., & Glintborg, D. (2021). Higher blood pressure in normal weight women with PCOS compared to controls, Endocrine Connections, 10(2), 154-163. Retrieved May 18, 2021, from

Higher blood pressure in normal weight women with PCOS compared to controls

Saved in:
Author: Mellembakken, Jan Roar1; Mahmoudan, Azita1; Mørkrid, Lars2;
Organizations: 1Division of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway
2Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway
3Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
4Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland
5Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Uusimaa, Finland
6Department of Women’s and Children’s Health, Karolinska Institutet and Department of Gynecology and Reproductive Medicine, Stockholm, Sweden
7Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
8Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, UK
9Department of Gynecology and Obstetrics, St. Olav’s Hospital, Trondheim, Norway
10Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
11Department of Endocrinology, Odense University Hospital, Odense, Denmark
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link:
Language: English
Published: Bioscientifica, 2021
Publish Date: 2021-05-18


Objective: Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI.

Methods: From a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI < 25 kg/m² (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles).

Results: The median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m². Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS.

Conclusions: Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

see all

Series: Endocrine connections
ISSN: 2049-3614
ISSN-E: 2049-3614
ISSN-L: 2049-3614
Volume: 10
Issue: 2
Pages: 154 - 163
DOI: 10.1530/EC-20-0527
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Copyright information: © 2021 The authors 2021. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.