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Maternal vitamin C and iron intake during pregnancy and the risk of islet autoimmunity and type 1 diabetes in children : a birth cohort study |
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| Author: | Mattila, Markus1,2,3; Hakola, Leena1,2; Niinistö, Sari3; |
| Organizations: |
1Unit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland 2Research, Development and Innovation Center, Tampere University Hospital, P.O. Box 2000, FI-33521 Tampere, Finland 3Health and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland
4Population Health Unit, Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland
5Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland 6Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland 7PEDEGO Research Unit, Department of Pediatrics, Medical Research Center, University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland 8Department of Children and Adolescents, Oulu University Hospital, P.O. Box 10, FI-90029 Oulu, Finland 9Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland 10Folkhälsan Research Center, FI-00251 Helsinki, Finland 11Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland 12Department of Pediatrics, Tampere University Hospital, FI-33521 Tampere, Finland 13Center for Child Health Research, Tampere University and Tampere University Hospital, FI-33014 Tampere, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2021051830268 |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute,
2021
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| Publish Date: | 2021-05-18 |
| Description: |
AbstractOur aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring’s risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) prospective birth cohort including children genetically at risk of type 1 diabetes born between 1997–2004. The diets of 4879 mothers in late pregnancy were assessed with a validated food frequency questionnaire. The outcomes were islet autoimmunity and type 1 diabetes. Cox proportional hazards regression analysis adjusted for energy, family history of diabetes, human leukocyte antigen (HLA) genotype and sex was used for statistical analyses. Total intake of vitamin C or iron from food and supplements was not associated with the risk of islet autoimmunity (vitamin C: HR 0.91: 95% CI (0.80, 1.03), iron: 0.98 (0.87, 1.10)) or type 1 diabetes (vitamin C: 1.01 (0.87, 1.17), iron: 0.92 (0.78, 1.08)), neither was the use of vitamin C or iron supplements associated with the outcomes. In conclusion, no association was found between maternal vitamin C or iron intake during pregnancy and the risk of islet autoimmunity or type 1 diabetes in the offspring. see all
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| Series: |
Nutrients |
| ISSN: | 2072-6643 |
| ISSN-E: | 2072-6643 |
| ISSN-L: | 2072-6643 |
| Volume: | 13 |
| Issue: | 3 |
| Article number: | 928 |
| DOI: | 10.3390/nu13030928 |
| OADOI: | https://oadoi.org/10.3390/nu13030928 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics 3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
Supported by the EFSD/JDRF/Lilly European Programme in Type 1 Diabetes Research; Doctoral Programs in Public Health; the Academy of Finland (grants 63672, 79685, 79686, 80846, 126813, 201988, 210632, 276475); Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (grants 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L117, 9M114, 9N086, 9P057, 9R055, 9S074, 9U065, 9V072, 9X062); the Juvenile Diabetes Research Foundation (grants 197032, 4-1998-274, 4-1999-731, and 4-2001-435); the Novo Nordisk Foundation; the European Union Biomed 2 Program (BMH4-CT98-3314); Doctoral Programme in Health Sciences, Tampere University and The Jenny and Antti Wihuri Foundation. |
| Copyright information: |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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https://creativecommons.org/licenses/by/4.0/ |