University of Oulu

Kajantie, E, Johnson, S, Heinonen, K, et al.; APIC Adults Born Preterm International Collaboration. Common Core Assessments in follow-up studies of adults born preterm—Recommendation of the Adults Born Preterm International Collaboration. Paediatr Perinat Epidemiol. 2021; 35: 371– 387.

Common Core Assessments in follow-up studies of adults born preterm : recommendation of the Adults Born Preterm International Collaboration

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Author: Kajantie, Eero1,2,3,4; Johnson, Samantha5; Heinonen, Kati6;
Organizations: 1Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland
2PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
4Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
5Department of Health Sciences, University of Leicester, Leicester, UK
6Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
7Turner Institute for Brain & Mental Health, Monash University, Melbourne, Vic., Australia
8Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Vic., Australia
9Department of Psychology, University of Warwick, Coventry, UK
10Warwick Medical School, University of Warwick, Coventry, UK
11Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
12Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway
13Unit for Physiotherapy Services, Trondheim Municipality, Trondheim, Norway
14Department of Paediatrics, University of Otago, Christchurch, New Zealand
15Department of Child Health, The Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands
16Department of Child and Family Studies, University of Tennessee Knoxville, Knoxville, TN, USA
17Department of Pediatrics, Tampere University and Tampere University Hospital, Tampere, Finland
18Department of Pediatrics, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada
19Research Office, Departments of Obstetrics and Gynaecology and of Paediatrics, The Royal Women's Hospital, University of Melbourne, Melbourne, Vic., Australia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-06-08


Background: Of all newborns, 1%-2% are born very preterm (VP; <32 weeks) or with very low birthweight (VLBW; ≤1500 g). Advances in prenatal and neonatal care have substantially improved their survival, and the first generations who have benefited from these advances are now entering middle age. While most lead healthy lives, on average these adults are characterised by a number of adversities. These include cardiometabolic risk factors, airway obstruction, less physical activity, poorer visual function, lower cognitive performance, and a behavioural phenotype that includes inattention and internalising and socially withdrawn behaviour that may affect life chances and quality of life. Outcomes in later adulthood are largely unknown, and identifying trajectories of risk or resilience is essential in developing targeted interventions. Joint analyses of data and maintenance of follow-up of cohorts entering adulthood are essential. Such analyses are ongoing within the Adults Born Preterm International Collaboration (APIC; Joint analyses require data harmonisation, highlighting the importance of consistent assessment methodologies.

Objective: To present an expert recommendation on Common Core Assessments to be used in follow-up assessments of adults born preterm.

Methods: Principles of Common Core Assessments were discussed at APIC meetings. Experts for each specific outcome domain wrote the first draft on assessments pertaining to that outcome. These drafts were combined and reviewed by all authors. Consensus was reached by discussion at APIC meetings.

Results: We present a recommendation by APIC experts on consistent measures to be used in adult follow-up assessments.

Conclusions: The recommendation encompasses both “core” measures which we recommend to use in all assessments of adults born preterm that include the particular outcome. This will allow comparability between time and location. The recommendation also lists optional measures, focusing on current gaps in knowledge. It includes sections on study design, cardiometabolic and related biomarkers, biological samples, life style, respiratory, ophthalmic, cognitive, mental health, personality, quality of life, sociodemographics, social relationships, and reproduction.

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Series: Paediatric and perinatal epidemiology
ISSN: 0269-5022
ISSN-E: 1365-3016
ISSN-L: 0269-5022
Volume: 35
Issue: 3
Pages: 371 - 387
DOI: 10.1111/ppe.12694
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: Academy of Finland (to EK, KH, KR, and PH), Canadian Institutes of Health Research Operating grant (#MOP – 119386 to KMM), Cure Kids NZ (to BAD), European Commission (Horizon 2020 award 733280 RECAP-preterm; to EK, DW, EV, KAIE, KH, KR, MSI, PH, SJ, and SvdP), Foundation for Pediatric Research (to EK), National Health & Medical Research Council, Australia (to PJA and LWD), Norface DIAL (Consortium 462-16-040 Premlife to EK, DW, KR), Signe and Ane Gyllenberg Foundation (to EK, KR), and Sigrid Juselius Foundation (to EK).
EU Grant Number: (956454) RecaP - Capture, recycling and societal management of phosphorus in the environment
Copyright information: © 2020 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.