Mononen ME, Kettunen HP, Suoranta SK, Kärkkäinen MS, Selander TA, Purokivi MK, Kaarteenaho RL. Several specific high-resolution computed tomography patterns correlate with survival in patients with idiopathic pulmonary fibrosis. J Thorac Dis 2021;13(4):2319-2330. doi: 10.21037/jtd-20-1957
Several specific high-resolution computed tomography patterns correlate with survival in patients with idiopathic pulmonary fibrosis
|Author:||Mononen, Minna E.1,2; Kettunen, Hannu-Pekka3; Suoranta, Sanna-Katja3;|
1Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
2Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
3Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
4Kuopio City Home Care, Rehabilitation and Medical Services for Elderly, Kuopio, Finland
5Science Services Center, Kuopio University Hospital, Kuopio, Finland
6Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 2.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021060936000
AME Publishing Company,
|Publish Date:|| 2021-06-09
Background: Evidence of honeycombing in high-resolution computed tomography (HRCT) is a recognized risk factor for shortened survival in patients with idiopathic pulmonary fibrosis (IPF), but few studies have evaluated the feasibility of exploiting other specific patterns for predicting survival. The aim of this study was to examine the extent of specific HRCT patterns in IPF and determine whether they correlate with clinical features, pulmonary function tests (PFT), and survival.
Methods: Both the presence and extent of specific HRCT patterns, such as traction bronchiectasis, honeycombing, architectural distortion, reticulation, emphysema, and ground glass opacity, in 129 HRCT examinations were scored semi-quantitatively in three zones of each lung. HRCT examinations were also re-classified according to the 2011 and 2018 international statements. Correlations were calculated between the scores of specific HRCT patterns, clinical features, PFT, and patient survival.
Results: The extent of traction bronchiectasis was found to be an independent risk factor of shortened survival (HR 1.227, P=0.001). Patients with a possible usual interstitial pneumonia (UIP) pattern had a better median survival than the patients with a definite UIP pattern (61 vs. 37 months, P=0.026). The extents of traction bronchiectasis, honeycombing, and architectural distortion displayed an inverse correlation with all PFT values at the time of diagnosis. There were few differences between the radiological classifications of the 2011 and 2018 international statements.
Journal of thoracic disease
|Pages:||2319 - 2330|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
The Foundation of the Finnish Anti-Tuberculosis Association to MM, RK; Väinö and Laina Kivi Foundation to MM; Center of Medicine and Clinical Research, Kuopio University Hospital to MM; the Research Foundation of Kuopio University Hospital to MM; a state subsidy of the Kuopio University Hospital to RK; the Research Foundation of Pulmonary Diseases to MM, RK; the Research Foundation of Northern Finland to RK, and the Jalmari and Rauha Ahokas Foundation to MM, RK.
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