Paavola, T., Bergmann, U., Kuusisto, S., Kakko, S., Savolainen, M. J., & Salonurmi, T. (2021). Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease—Family Study. International Journal of Molecular Sciences, 22(9), 4908. doi:10.3390/ijms22094908
Distinct fatty acid compositions of hdl phospholipids are characteristic of metabolic syndrome and premature coronary heart disease—family study
|Author:||Paavola, Timo1,2; Bergmann, Ulrich3; Kuusisto, Sanna4,5;|
1Research Center for Internal Medicine, Department of Internal Medicine, Oulu University Hospital and University of Oulu, 90200 Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90200 Oulu, Finland
3Protein Analysis Core Facility, Biocenter Oulu, University of Oulu, 90570 Oulu, Finland
4Computational Medicine, Faculty of Medicine, Biocenter Oulu, University of Oulu, 90570 Oulu, Finland
5NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021061638185
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2021-06-16
HDL particles can be structurally modified in atherosclerotic disorders associated with low HDL cholesterol level (HDL-C). We studied whether the lipidome of the main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species of HDL2 and HDL3 subfractions is associated with premature coronary heart disease (CHD) or metabolic syndrome (MetS) in families where common low HDL-C predisposes to premature CHD. The lipidome was analyzed by LC-MS. Lysophosphatidylcholines were depleted of linoleic acid relative to more saturated and shorter-chained acids containing species in MetS compared with non-affected subjects: the ratio of palmitic to linoleic acid was elevated by more than 30%. A minor PC (16:0/16:1) was elevated (28–40%) in MetS. The contents of oleic acid containing PCs were elevated relative to linoleic acid containing PCs in MetS; the ratio of PC (16:0/18:1) to PC (16:0/18:2) was elevated by 11–16%. Certain PC and SM ratios, e.g., PC (18:0/20:3) to PC (16:0/18:2) and a minor SM 36:2 to an abundant SM 34:1, were higher (11–36%) in MetS and CHD. The fatty acid composition of certain LPCs and PCs displayed a characteristic pattern in MetS, enriched with palmitic, palmitoleic or oleic acids relative to linoleic acid. Certain PC and SM ratios related consistently to CHD and MetS.
International journal of molecular sciences
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This research was funded by Sigrid Jusélius Foundation (to M.J.S.), Lääketieteen lisensiaatti Paavo Ilmari Ahvenaisen säätiö (to T.P.), the Finnish Cultural Foundation (to T.P.), the Finnish Foundation for Cardiovascular Research (to M.J.S. and to T.P.), Paavo Nurmi Foundation (to T.P.), Aarne Koskelo Foundation (to T.P.) and the Finnish Medical Foundation (to T.P.).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).