University of Oulu

Julku, H., Rouhinen, S., Huttunen, H.J. et al. Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity. Sci Rep 11, 8310 (2021). https://doi.org/10.1038/s41598-021-87545-9

Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity

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Author: Julku, Hanna1,2; Rouhinen, Santeri1,2; Huttunen, Henri J.1,3;
Organizations: 1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, 00014, Helsinki, Finland
2BioMag Laboratory, HUS Medical Imaging Center, Helsinki, Finland
3Herantis Pharma Plc, Bertel Jungin aukio 1, 02600, Espoo, Finland
4Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland
5Department of Ophthalmology, Oulu University Hospital, Medical Research Center (MCR), University of Oulu, Oulu, Finland
6Department of Ophthalmology, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland
7Tays Eye Center, Tampere University Hospital, Tampere, Finland
8Centre for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK
9Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 5.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021070240956
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-07-02
Description:

Abstract

Amblyopia is a developmental disorder associated with abnormal visual experience during early childhood commonly arising from strabismus and/or anisometropia and leading to dysfunctions in visual cortex and to various visual deficits. The different forms of neuronal activity that are attenuated in amblyopia have been only partially characterized. In electrophysiological recordings of healthy human brain, the presentation of visual stimuli is associated with event-related activity and oscillatory responses. It has remained poorly understood whether these forms of activity are reduced in amblyopia and whether possible dysfunctions would arise from lower- or higher-order visual areas. We recorded neuronal activity with magnetoencephalography (MEG) from anisometropic amblyopic patients and control participants during two visual tasks presented separately for each eye and estimated neuronal activity from source-reconstructed MEG data. We investigated whether event-related and oscillatory responses would be reduced for amblyopia and localized their cortical sources. Oscillation amplitudes and evoked responses were reduced for stimuli presented to the amblyopic eye in higher-order visual areas and in parietal and prefrontal cortices. Importantly, the reduction of oscillation amplitudes but not that of evoked responses was correlated with decreased visual acuity in amblyopia. These results show that attenuated oscillatory responses are correlated with visual deficits in anisometric amblyopia.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 11
Issue: 1
Article number: 8310
DOI: 10.1038/s41598-021-87545-9
OADOI: https://oadoi.org/10.1038/s41598-021-87545-9
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
Subjects:
Funding: This study was supported by the Sigrid Juselius foundation and the Academy of Finland to S.P. (SA 266402, SA 273807) and J.M.P. (SA 253130), and Oskar Öflund Foundation to H.J.
Copyright information: © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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