University of Oulu

Tuokkola, J., Lamminsalo, A., Metsälä, J., Takkinen, H.-M., Tapanainen, H., Åkerlund, M., Niinistö, S., Toppari, J., Ilonen, J., Veijola, R., Knip, M., Kaila, M., & Virtanen, S. M. (2020). Maternal antioxidant intake during pregnancy and the development of cows’ milk allergy in the offspring. British Journal of Nutrition, 125(12), 1386–1393.

Maternal antioxidant intake during pregnancy and the development of cows’ milk allergy in the offspring

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Author: Tuokkola, Jetta1,2; Lamminsalo, Anni3; Metsälä, Johanna2;
Organizations: 1New Children’s Hospital and Clinical Nutrition Unit, Internal Medicine and Rehabilitation, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland
2Public Health Promotion Unit, Finnish institute for health and welfare, 00271 Helsinki, Finland
3Faculty of Social Sciences/Health Sciences, Tampere University, 33014, Tampere, Finland
4Department of Pediatrics, University of Turku, 20014, Turku, Finland
5Department of Clinical Microbiology, University of Eastern Finland, 70211, Kuopio, Finland
6Immunogenetics Laboratory, University of Turku, 20014, Turku, Finland
7Department of Paediatrics, University of Oulu, 90014 Oulu, Finland
8Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
9Folkhälsan Research Institute, 00251, Helsinki, Finland
10Center for Child Health Research, Tampere University, Tampere University Hospital, 33521, Tampere, Finland
11Public Health Medicine, University of Helsinki, Helsinki University Hospital, 00014, Helsinki, Finland
12Department of Paediatrics, Tampere University Hospital, 33521, Tampere, Finland
13Research, Development and Innovation Center, Tampere University Hospital, 33521 Tampere, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Cambridge University Press, 2021
Publish Date: 2021-07-06


Cows’ milk allergy (CMA) is the most common food allergy in young children, and it is often the first manifestation of atopic diseases. Accordingly, very early environmental factors, such as maternal diet during pregnancy, may play a role in the development of CMA, but the evidence is limited. The aim of this study was to investigate the association between maternal intake of antioxidant nutrients during pregnancy and the subsequent development of CMA in the offspring in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study. Maternal dietary information during pregnancy was collected with a detailed, validated FFQ. The maternal dietary information and the information on putative confounding factors were available for 4403 children. Information on diagnosed CMA (n 448) was obtained from a medical registry and queried from the parents up to child’s age of 3 years. The Finnish food composition database was used to calculate the average daily intake of nutrients. Logistic regression was applied for statistical analyses, and the nutrient intakes were adjusted for energy intake. OR are presented per 1 sd increment of the particular nutrient intake. Maternal total and dietary intake of β-carotene was associated with an increased risk of CMA in the offspring when adjusted for the putative confounding factors (total OR 1·10, 95 % CI 1·02, 1·20; dietary OR 1·10; 95 % CI 1·01, 1·19). Using dietary supplements containing antioxidants in addition to a balanced diet may not confer any additional benefits.

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Series: British journal of nutrition
ISSN: 0007-1145
ISSN-E: 1475-2662
ISSN-L: 0007-1145
Volume: 125
Issue: 12
Pages: 1386 - 1393
DOI: 10.1017/S0007114520003633
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Funding: The study was supported by the Academy of Finland (grants 63672, 79685, 79686, 80846, 201988, 210632, 129492, 126813, 276475), the Finnish Paediatric Research Foundation, the Juho Vainio Foundation, the Yrjö Jahnsson Foundation, the Competitive Research Funding of the Tampere University Hospital (grants 9L035, 9M029, 9P017, 9P057, 9R012, 9R055, 9S015, 9S074, 9T072, 9U016, 9U065, 9V012), Medical Research Funds of Turku and Oulu University Hospitals, the European Foundation for the Study of Diabetes, the Juvenile Diabetes Research Foundation (grants 197032, 4-1998-274, 4-1999-731, 4-2001-435), the Novo Nordisk Foundation and EU Biomed 2 (BMH4-CT98-3314), Doctoral Programs for Public Health, Foundation for Allergy Research, Research Foundation of Orion Corporation, Tampere Tuberculosis Foundation, Päivikki and Sakari Sohlberg foundation and the Jalmari and Rauha Ahokas Foundation.
Copyright information: © The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society.