Obesity and brain vulnerability in normal and abnormal aging : a multimodal MRI study
|Author:||Dake, Manmohi D.1; De Marco, Matteo1; Blackburn, Daniel J.1;|
1Department of Neuroscience, University of Sheffield, Sheffield, UK
2Academic Unit of Radiology, University of Sheffield, Sheffield, UK
3Department of Neurology, University of Eastern Finland, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021070741214
|Publish Date:|| 2021-07-07
Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer’s disease is unclear.
Objective: We used multimodal neuroimaging to clarify this relationship.
Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity.
Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction.
Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer’s disease dementia could help preserve brain structure in the presence of age and disease-related weight loss.
Journal of Alzheimer's disease reports
|Pages:||65 - 77|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This study was supported by the European Union Seventh Framework Programme (FP7/2007 –2013) under grant agreement no. 601055, VPH-DARE@IT to IDW, HS and AV). MDM and AV also acknowledge the support from Neurocare. MDD is supported by a Faculty of Medicine, Dentistry and Health PhD scholarship.
© 2021 – The authors. Published by IOS Press. This is an Open Access article distributed underthe terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).