University of Oulu

Dake, Manmohi D. et al. ‘Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study’. 1 Jan. 2021 : 65–77.

Obesity and brain vulnerability in normal and abnormal aging : a multimodal MRI study

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Author: Dake, Manmohi D.1; De Marco, Matteo1; Blackburn, Daniel J.1;
Organizations: 1Department of Neuroscience, University of Sheffield, Sheffield, UK
2Academic Unit of Radiology, University of Sheffield, Sheffield, UK
3Department of Neurology, University of Eastern Finland, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: IOS Press, 2021
Publish Date: 2021-07-07


Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer’s disease is unclear.

Objective: We used multimodal neuroimaging to clarify this relationship.

Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity.

Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction.

Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer’s disease dementia could help preserve brain structure in the presence of age and disease-related weight loss.

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Series: Journal of Alzheimer's disease reports
ISSN: 2542-4823
ISSN-E: 2542-4823
ISSN-L: 2542-4823
Volume: 5
Issue: 1
Pages: 65 - 77
DOI: 10.3233/ADR-200267
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
Funding: This study was supported by the European Union Seventh Framework Programme (FP7/2007 –2013) under grant agreement no. 601055, VPH-DARE@IT to IDW, HS and AV). MDM and AV also acknowledge the support from Neurocare. MDD is supported by a Faculty of Medicine, Dentistry and Health PhD scholarship.
Copyright information: © 2021 – The authors. Published by IOS Press. This is an Open Access article distributed underthe terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).