University of Oulu

Hautala, N., Partanen, T., Kubin, A.-M., Kauma, H., & Hautala, T. (2021). Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection. Viruses, 13(6), 1040. doi:10.3390/v13061040

Central nervous system and ocular manifestations in puumala hantavirus infection

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Author: Hautala, Nina1; Partanen, Terhi2; Kubin, Anna-Maria1;
Organizations: 1Medical Research Center, PEDEGO Research Unit, Department of Ophthalmology, Oulu University Hospital and University of Oulu, 90029 Oulu, Finland
2Research Unit of Internal Medicine, Department of Internal Medicine, Division of Infectious Diseases, Oulu University and Oulu University Hospital, 90014 Oulu, Finland
3Research Unit of Biomedicine, University of Oulu, 90029 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2021
Publish Date: 2021-07-08


Puumala hantavirus (PUUV), carried and spread by the bank vole (Myodes glareolus), causes a mild form of hemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE). Acute high fever, acute kidney injury (AKI), thrombocytopenia, and hematuria are typical features of this syndrome. In addition, headache, blurred vision, insomnia, vertigo, and nausea are commonly associated with the disease. This review explores the mechanisms and presentations of ocular and central nervous system involvement in acute NE.

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Series: Viruses
ISSN: 1999-4915
ISSN-E: 1999-4915
ISSN-L: 1999-4915
Volume: 13
Issue: 6
Article number: 1040
DOI: 10.3390/v13061040
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3125 Otorhinolaryngology, ophthalmology
Copyright information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (