University of Oulu

Tuija M Mikkola, PhD, Minna K Salonen, PhD, Eero Kajantie, MD, PhD, Hannu Kautiainen, MSc, Johan G Eriksson, MD, DMSc, Associations of Fat and Lean Body Mass with Circulating Amino Acids in Older Men and Women, The Journals of Gerontology: Series A, Volume 75, Issue 5, May 2020, Pages 885–891, https://doi.org/10.1093/gerona/glz126

Associations of fat and lean body mass with circulating amino acids in older men and women

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Author: Mikkola, Tuija M.1; Salonen, Minna K.1,2; Kajantie, Eero2,3,4,5;
Organizations: 1Folkhälsan Research Center, Helsinki, Finland
2Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
3PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Finland
4Department of Clinical and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway
5Children’s Hospital, Helsinki University Hospital and University of Helsinki, Finland
6Primary Health Care Unit, Kuopio University Hospital, Finland
7Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Finland
8Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research
9Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021082043765
Language: English
Published: Oxford University Press, 2020
Publish Date: 2020-05-16
Description:

Abstract

Circulating amino acids are potential markers of body composition. Previous studies are mainly limited to middle age and focus on either fat or lean mass, thereby ignoring overall body composition. We investigated the associations of fat and lean body mass with circulating amino acids in older men and women. We studied 594 women and 476 men from the Helsinki Birth Cohort Study (age 62–74 years). Bioelectrical impedance analysis was used to indicate two main body compartments by fat (fat mass/height²) and lean mass indices (lean mass/height²), dichotomized based on sex-specific medians. Eight serum amino acids were quantified using nuclear magnetic resonance spectroscopy. General linear models were adjusted for age, smoking, and fasting glucose. Higher lean mass index (LMI) was associated with higher concentrations of branched-chain amino acids in both sexes (p ≤ .001). In men, LMI was also positively associated with tyrosine (p = .006) and inversely with glycine (p < .001). Higher fat mass index was associated with higher concentrations of all branched-chain amino acids, aromatic amino acids (phenylalanine and tyrosine), and alanine in both sexes (p ≤ .008). Associations between body composition and amino acids are largely similar in older men and women. The associations are largely similar to those previously observed in younger adults.

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Series: Journals of gerontology. A, Biological sciences and medical sciences
ISSN: 1079-5006
ISSN-E: 1758-535X
ISSN-L: 1079-5006
Volume: 75
Issue: 5
Pages: 885 - 891
DOI: 10.1093/gerona/glz126
OADOI: https://oadoi.org/10.1093/gerona/glz126
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: This work was supported by Emil Aaltonen Foundation; The Diabetes Research Foundation; Lastentautien tutkimussäätiö, Novo Nordisk Fonden; Signe and Ane Gyllenberg Foundation; Sigrid Jusélius Foundation; Samfundet Folkhälsan; Finska Läkaresällskapet; Liv och Hälsa; European Commission within the 7th Framework Programme (DORIAN, grant agreement no. 278603); and European Union Horizon 2020 Programme (LifeCycle grant no.733206, DYNAHEALTH grant no. 633595, and RECAP grant no. SC1-2016-RTD-733180). The Academy of Finland supported E.K. (grant no. 127437, 129306, 130326, 134791, 263924 and 274794) and J.G.E. (grant no. 129369, 129907, 135072, 129255, and 126775).
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
Copyright information: © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journals of Gerontology, Series A following peer review. The version of record of: Tuija M Mikkola, PhD, Minna K Salonen, PhD, Eero Kajantie, MD, PhD, Hannu Kautiainen, MSc, Johan G Eriksson, MD, DMSc, Associations of Fat and Lean Body Mass with Circulating Amino Acids in Older Men and Women, The Journals of Gerontology: Series A, Volume 75, Issue 5, May 2020, Pages 885–891, is available online at: https://doi.org/10.1093/gerona/glz126.