University of Oulu

Meinilä, J., Perälä, MM., Kanerva, N. et al. Birth weight modifies the association between a healthy Nordic diet and office blood pressure in old age. J Hum Hypertens (2020). https://doi.org/10.1038/s41371-020-00423-1

Birth weight modifies the association between a healthy Nordic diet and office blood pressure in old age

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Author: Meinilä, Jelena1,2; Perälä, Mia-Maria1; Kanerva, Noora3;
Organizations: 1Folkhälsan Research Center, Helsinki, Finland
2Department of Gynecology and Obstetrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
3Department of Public Health, University of Helsinki, Helsinki, Finland
4Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
5Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Public Health Promotion Unit, National Institute for Health and Welfare, Oulu, Finland
7PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
8Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
9Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
10Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
11Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research A*STAR, Singapore, Singapore
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2021082544160
Language: English
Published: Springer Nature, 2020
Publish Date: 2021-10-13
Description:

Abstract

A healthy diet reduces risk for high blood pressure. A small body size at birth increases risk for high blood pressure. Our aim was to study whether birth weight modifies the association between a healthy Nordic diet, characterized by high intake of Nordic vegetables, fruits, and berries, whole-grain rye, oat, and barley, and rapeseed oil, and blood pressure. Finnish men and women (n = 960) born in 1934–1944 attended clinical visits including clinical measurements, and questionnaires in 2001–2004 and 2011–2013. Linear regression was applied to investigate the interactions between birth weight and Nordic diet (measured by the Baltic sea diet score (BSDS)) on blood pressure change during the 10-year follow-up. Baseline Nordic diet and birth weight showed a significant interaction on systolic blood pressure (SBP) (p = 0.02), and pulse pressure (PP) (p < 0.01) over a 10-year follow-up. In the lowest birth weight category (women < 2951 g, men < 3061 g), predicted SBP decreased across BSDS thirds (lowest (T1): 155 mmHg, highest (T3): 145 mmHg, p for linearity = 0.01) as did predicted PP (T1: 71 mmHg, T3: 63 mmHg, p < 0.01). In the middle birth weight category, predicted SBP increased across BSDS thirds (T1: 151 mmHg, T3: 155 mmHg, p = 0.02) as did predicted PP (T1: 67 mmHg, T3: 71 mmHg, p < 0.01). In the highest birth weight category, no associations were found. Higher adherence to a healthy Nordic diet was associated with lower SBP and PP in individuals with low birth weight but with higher SBP and PP in those with average birth weight.

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Series: Journal of human hypertension
ISSN: 0950-9240
ISSN-E: 0950-9240
ISSN-L: 0950-9240
Volume: In press
DOI: 10.1038/s41371-020-00423-1
OADOI: https://oadoi.org/10.1038/s41371-020-00423-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: This study was supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland (127437, 129306, 130326, 134791, 263924, and 315690), Samfundet Folkhälsan, Liv och Hälsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595, Horizon2020 award No. 733206 LifeCycle. (all for the Helsinki Birth Cohort Study), European Commission, Horizon2020 award 733280 RECAP), Foundation for Cardiovascular Research, Foundation for Diabetes Research, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Sigrid Jusélius Foundation.
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
Copyright information: © The Author(s) 2020. This is a post-peer-review, pre-copyedit version of an article published in J Hum Hypertens. The final authenticated version is available online at https://doi.org/10.1038/s41371-020-00423-1.