University of Oulu

Tickner, Ben. J., Zhivonitko, V. V., & Telkki, V.-V. (2021). Ultrafast Laplace NMR to study metal–ligand interactions in reversible polarisation transfer from parahydrogen. Physical Chemistry Chemical Physics, 23(31), 16542–16550. https://doi.org/10.1039/d1cp02383g

Ultrafast Laplace NMR to study metal–ligand interactions in reversible polarisation transfer from parahydrogen

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Author: Tickner, Ben. J.1; Zhivonitko, Vladimir V.1; Telkki, Ville-Veikko1
Organizations: 1NMR Research Unit, Faculty of Science, University of Oulu, 90014, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021082544212
Language: English
Published: Royal Society of Chemistry, 2021
Publish Date: 2021-08-25
Description:

Abstract

Laplace Nuclear Magnetic Resonance (NMR) can determine relaxation parameters and diffusion constants, giving valuable information about molecular structure and dynamics. Information about relaxation times (T₁ and T₂) and the self-diffusion coefficient (D) can be extracted from exponentially decaying NMR signals by performing a Laplace transform, which is a different approach to traditional NMR involving Fourier transform of a free induction decay. Ultrafast Laplace NMR uses spatial encoding to collect the entire data set in just a single scan which provides orders of magnitude time savings. In this work we use ultrafast Laplace NMR DT₂ correlation sequences to measure key relaxation (T₂) and diffusion (D) parameters of methanolic solutions containing pyridine. For the first time we combine this technique with the hyperpolarisation technique Signal Amplification By Reversible Exchange (SABRE), which employs an iridium catalyst to reversibly transfer polarisation from parahydrogen, to boost the ¹H NMR signals of pyridine by up to 300-fold. We demonstrate use of ultrafast Laplace NMR to monitor changes in pyridine T₂ and D associated with ligation to the iridium SABRE catalyst and kinetic isotope exchange reactions. The combined 1440-fold reduction in experiment time and 300-fold ¹H NMR signal enhancement allow the determination of pyridine D coefficients and T₂ values at 25 mM concentrations in just 3 seconds using SABRE hyperpolarised ultrafast Laplace NMR.

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Series: PCCP. Physical chemistry chemical physics
ISSN: 1463-9076
ISSN-E: 1463-9084
ISSN-L: 1463-9076
Volume: 23
Pages: 16542 - 16550
DOI: 10.1039/D1CP02383G
OADOI: https://oadoi.org/10.1039/D1CP02383G
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
116 Chemical sciences
Subjects:
Funding: Financial support from the European Research Council (Project number 2430273211), Academy of Finland (grant no. 323480) and the University of Oulu (Kvantum Institute) are gratefully acknowledged.
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
Academy of Finland Grant Number: 323480
Detailed Information: 323480 (Academy of Finland Funding decision)
Copyright information: © 2021 The Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
  https://creativecommons.org/licenses/by/3.0/