Lainiala, O., Karsikas, M., Reito, A. et al. Whole blood chromium concentration is very rarely elevated independently of whole blood cobalt. Sci Rep 11, 12352 (2021). https://doi.org/10.1038/s41598-021-91512-9
Whole blood chromium concentration is very rarely elevated independently of whole blood cobalt
|Author:||Lainiala, Olli1,; Karsikas, Mari1,2; Reito, Aleksi1,3;|
1Coxa Hospital for Joint Replacement and Faculty of Medicine and Health Technologies, Tampere University, Niveltie 4, 33520 Tampere, Finland
2Center for Life Course Health Research, University of Oulu, P.O.Box 8000, 90014 Oulu, Finland
3Department of Orthopaedics and Traumatology, Tampere University Hospital, Kuntokatu 2, 33520 Tampere, Finland
|Online Access:||PDF Full Text (PDF, 1.8 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021090345097
|Publish Date:|| 2021-09-03
Due to the risk of adverse reactions to metal debris resulting from increased wear of the arthroplasty more than one million metal-on-metal (MoM) hip replacements worldwide are in active follow-up. Follow-up usually includes measurement of both whole blood cobalt (Co) and chromium (Cr) concentrations. Our experience is that Cr is seldom independently elevated. We wanted to ascertain whether blood Cr measurements could be omitted from follow-up protocols without lowering the quality of follow-up. We identified 8438 whole blood Co and Cr measurements performed without or prior to revision surgery. When the cut-off levels 5 µg/L and 7 µg/L were used, Cr was independently elevated in only 0.5% (95% confidence interval, CI, 0.3 to 0.6) and 0.2% (CI 0.1 to 0.3) of the measurements. The models with continuous variables showed that the higher the blood metal concentrations are the lower the percentage of measurements with Cr higher than Co. Our results suggest that whole blood Cr is very rarely independently elevated and therefore the authorities should consider omitting Cr measurements from their screening guidelines of MoM hip replacements. We believe this change in practice would simplify follow-up and lead to cost savings without decreasing the quality of follow-up.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
Our institution received funding from the research funds of our hospital district, representing public funding.
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