University of Oulu

Kairaluoma, V, Kemi, N, Huhta, H, Pohjanen, V-M, Helminen, O. Toll-like receptor 5 and 8 in hepatocellular carcinoma. APMIS. 2021; 129: 470– 479

Toll-like receptor 5 and 8 in hepatocellular carcinoma

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Author: Kairaluoma, Valtteri1; Kemi, Niko1; Huhta, Heikki1;
Organizations: 1Surgery Research Unit, Medical Research Center Oulu, Cancer and Translational Medicine Research Unit,University of Oulu and Oulu University Hospital, Oulu, Finland
2Cancer and Translational MedicineResearch Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2021090945654
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2022-05-05
Description:

Abstract

Toll-like receptors (TLRs) are components of innate immunity, but also have a role in carcinogenesis. The prognostic value of TLR5 and TLR8 tumor expression was examined in contrast with known risk markers Ki67 and p53. All HCC patients from Oulu University Hospital with available representative tumor sample were included in this study (n = 182). TLR5, TLR8, Ki67, and p53 expression were investigated by immunohistochemistry. The relation between patient survival and TLR, Ki67, and p53 expression was calculated with Cox regression adjusted for confounding factors. TLR5 cytoplasm intensity was associated with 5-year overall (strong 0.0% vs weak 23.4%, p < 0.001) and disease-specific (strong 0.0% vs weak 34.9%, p < 0.001) survival. TLR5 nuclei percentage was associated with poor 5-year disease-specific survival (high 16.3% vs low 31.5%, p = 0.022). In adjusted analysis, strong TLR5 cytoplasm intensity was an independent risk factor for poor 5-year overall (adjusted HR 1.88, 95% CI 1.26–2.81) and disease-specific (adjusted HR 2.00, 95% CI 1.27–3.15) survival. High Ki67 and p53 expression associated with 5-year overall- and disease-specific survival. TLR8 was not associated with patient survival. This study suggests that TLR5 expression is independently prognostic in HCC with similar point estimate as previously known p53.

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Series: APMIS
ISSN: 0903-4641
ISSN-E: 1600-0463
ISSN-L: 0903-4641
Volume: 129
Issue: 8
Pages: 470 - 479
DOI: 10.1111/apm.13142
OADOI: https://oadoi.org/10.1111/apm.13142
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
p53
Funding: This work was supported by grants from The Finnish Medical Foundation (V.K.), Instrumentarium Science Foundation (O.H.) and Georg C. and Mary Ehrnrooth Foundation and Finnish State Research Fund (H.H. and O.H.).
Copyright information: © 2021 Scandinavian Societies for Medical Microbiology and Pathology. This is the peer reviewed version of the following article: Kairaluoma, V, Kemi, N, Huhta, H, Pohjanen, V-M, Helminen, O. Toll-like receptor 5 and 8 in hepatocellular carcinoma. APMIS. 2021; 129: 470– 479, which has been published in final form at https://doi.org/10.1111/apm.13142. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.