Jääskeläinen, T., Kärkkäinen, O., Jokkala, J. et al. A non-targeted LC–MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies. Metabolomics 17, 20 (2021). https://doi.org/10.1007/s11306-020-01752-5
A non-targeted LC–MS metabolic profiling of pregnancy : longitudinal evidence from healthy and pre-eclamptic pregnancies
|Author:||Jääskeläinen, Tiina1,2; Kärkkäinen, Olli3,4; Jokkala, Jenna3;|
1Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Department of Food and Nutrition, University of Helsinki, Helsinki, Finland
3Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
4School of Pharmacy, University of Eastern Finland, Kuopio, Finland
5Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Department of Biochemistry, Food Chemistry and Food Development Unit, University of Turku, Turku, Finland
7Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
8Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University Hospital and University of Tampere, Tampere, Finland
|Online Access:||PDF Full Text (PDF, 2.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021092046654
|Publish Date:|| 2021-09-20
Introduction: Maternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation.
Objectives and methods: We applied liquid chromatography–mass spectrometry (LC–MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy.
Results: Progression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls.
Conclusions: Our study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se.
Collaborators for The FINNPEC Core Investigator Group
Eero Kajantie (Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland). Juha Kere (Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden; Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland; Folkhälsan Institute of Genetics, Helsinki, Finland), Katja Kivinen (Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland), Anneli Pouta (Department of Government Services, National Institute for Health and Welfare, Helsinki, Finland).
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
Open access funding provided by University of Helsinki including Helsinki University Central Hospital. Funding was received from the Competitive State Research Financing of the Expert Responsibility are of Helsinki University Hospital (TYH2018305), Jane and Aatos Erkko Foundation, Päivikki and Sakari Sohlberg Foundation, Academy of Finland (Grants 121196, 134957, and 278941, 277986), Research Funds of the University of Helsinki, Finnish Medical Foundation, Finska Läkaresällskapet, Novo Nordisk Foundation, Finnish Foundation for Pediatric Research, Emil Aaltonen Foundation, Juho Vainio Foundation, Sigrid Jusélius Foundation, the Finnish Foundation for Alcohol Studies, Business Finland and Biocenter Finland.
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