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A non-targeted LC–MS metabolic profiling of pregnancy : longitudinal evidence from healthy and pre-eclamptic pregnancies |
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| Author: | Jääskeläinen, Tiina1,2; Kärkkäinen, Olli3,4; Jokkala, Jenna3; |
| Organizations: |
1Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 2Department of Food and Nutrition, University of Helsinki, Helsinki, Finland 3Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
4School of Pharmacy, University of Eastern Finland, Kuopio, Finland
5Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 6Department of Biochemistry, Food Chemistry and Food Development Unit, University of Turku, Turku, Finland 7Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland 8Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University Hospital and University of Tampere, Tampere, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 2.4 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2021092046654 |
| Language: | English |
| Published: |
Springer Nature,
2021
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| Publish Date: | 2021-09-20 |
| Description: |
AbstractIntroduction: Maternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation. Objectives and methods: We applied liquid chromatography–mass spectrometry (LC–MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy. Results: Progression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls. Conclusions: Our study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se. see all
Collaborators for The FINNPEC Core Investigator GroupEero Kajantie (Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland). Juha Kere (Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden; Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland; Folkhälsan Institute of Genetics, Helsinki, Finland), Katja Kivinen (Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland), Anneli Pouta (Department of Government Services, National Institute for Health and Welfare, Helsinki, Finland). see all
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| Series: |
Metabolomics |
| ISSN: | 1573-3882 |
| ISSN-E: | 1573-3890 |
| ISSN-L: | 1573-3882 |
| Volume: | 17 |
| Article number: | 20 |
| DOI: | 10.1007/s11306-020-01752-5 |
| OADOI: | https://oadoi.org/10.1007/s11306-020-01752-5 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
Open access funding provided by University of Helsinki including Helsinki University Central Hospital. Funding was received from the Competitive State Research Financing of the Expert Responsibility are of Helsinki University Hospital (TYH2018305), Jane and Aatos Erkko Foundation, Päivikki and Sakari Sohlberg Foundation, Academy of Finland (Grants 121196, 134957, and 278941, 277986), Research Funds of the University of Helsinki, Finnish Medical Foundation, Finska Läkaresällskapet, Novo Nordisk Foundation, Finnish Foundation for Pediatric Research, Emil Aaltonen Foundation, Juho Vainio Foundation, Sigrid Jusélius Foundation, the Finnish Foundation for Alcohol Studies, Business Finland and Biocenter Finland. |
| Copyright information: |
© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |