University of Oulu

Deckers, K, Köhler, S, Ngandu, T, et al. Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index. Alzheimer's Dement. 2021; 17: 1205– 1212. https://doi.org/10.1002/alz.12281

Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index

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Author: Deckers, Kay1; Köhler, Sebastian1; Ngandu, Tiia2,3;
Organizations: 1Alzheimer Centrum Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
2Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
3Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
4Center for Life Course Health Research, University of Oulu, Oulu, Finland
5Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
6Oulu City Hospital, Oulu, Finland
7Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
8Hospital District of North Karelia, Joensuu, Finland
9Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
10Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
11University of Helsinki and Helsinki University Hospital, Helsinki, Finland
12Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021100549377
Language: English
Published: Elsevier, 2021
Publish Date: 2021-10-05
Description:

Abstract

Introduction: Individuals in early dementia prevention trials may differ in how much they benefit from interventions depending on their initial risk level. Additionally, modifiable dementia risk scores might be used as surrogate/intermediate outcomes.

Methods: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated in post hoc analyses (N = 1207) whether the cognitive benefits of the 2-year multi-domain lifestyle intervention differed by baseline dementia risk measured with the “LIfestyle for BRAin Health” (LIBRA) score. We also investigated intervention effects on change in LIBRA score over time.

Results: Overall, higher baseline LIBRA was related to less cognitive improvement over time. This association did not differ between the intervention and control groups. The intervention was effective in decreasing LIBRA scores over time, regardless of baseline demographics or cognition.

Discussion: The cognitive benefit of the FINGER intervention was similar across individuals with different LIBRA scores at baseline. Furthermore, LIBRA may be useful as a surrogate/intermediate endpoint and surveillance tool to monitor intervention success during trial execution.

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Series: Alzheimer's & dementia. The journal of the Alzheimer's Association
ISSN: 1552-5260
ISSN-E: 1552-5279
ISSN-L: 1552-5260
Volume: 17
Issue: 7
Pages: 1205 - 1212
DOI: 10.1002/alz.12281
OADOI: https://oadoi.org/10.1002/alz.12281
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: K. Deckers received funding from the Young European Research Universities (YERUN) Research Mobility Award and a travel fellowship from Alzheimer Nederland. T. Ngandu received research funding from EU Joint Programme–Neurodegenerative Disease Research (EURO-FINGERS) and Finnish Cultural Foundation, Juho Vainio Foundation, and Jalmari and Rauha Ahokas Foundation, Finland. R. Antikainen received research funding from EVO/VTR grants of Oulu University Hospital and Oulu City Hospital (Finland). H. Soininen received funding from EU 7th framework collaborative project grant (HATICE), EU Joint Programme–Neurodegenerative Disease Research (MIND-AD), UEF Strategic funding for UEFBRAIN (Finland), and EVO/VTR funding from Kuopio University Hospital (Finland). M. Kivipelto received research support from the Academy of Finland (317465), Finnish Social Insurance Institution, Finnish Ministry of Education and Culture, Juho Vainio Foundation (Finland), EU Joint Programme–Neurodegenerative Disease Research (MIND-AD and EURO-FINGERS), Alzheimer's Research and Prevention Foundation (US), Alzheimerfonden (Sweden), Swedish Research Council, Center for Innovative Medicine (CIMED) at Karolinska Institutet, Region Stockholm (ALF, NSV), Knut and Alice Wallenberg Foundation (Sweden), Stiftelsen Stockholms sjukhem (Sweden), Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse (Sweden). A. Solomon received research funding from the European Research Council grant 804371, Academy of Finland (287490, 294061, 319318), Finnish Cultural Foundation, Yrjö Jahnsson Foundation (Finland), Alzheimerfonden, and Region Stockholm ALF (Sweden). The funding sources had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
Copyright information: © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
  https://creativecommons.org/licenses/by-nc-nd/4.0/