University of Oulu

Kaya, M., Bilican, I., Mujtaba, M., Sargin, I., Erginer Haskoylu, M., Toksoy Oner, E., Zheng, K., Boccaccini, A. R., Cansaran-Duman, D., Onses, M. S., Torun, I., Akyuz, L., Elbuken, C., & Sørensen, M. V. (2021). Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications. Chemical Engineering Journal, 407, 126667.

Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications

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Author: Kaya, Murat1; Bilican, Ismail2,3; Mujtaba, Muhammad4;
Organizations: 1Department of Biotechnology and Molecular Biology, Faculty of Science and Letters, Aksaray University, 68100 Aksaray, Turkey
2Department of Electronics and Automation, Technical Vocational School, Aksaray University, 68100 Aksaray, Turkey
3UNAM—National Nanotechnology Research Center, Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey
4Institute of Biotechnology, Ankara University, 06110 Ankara, Turkey
5Selcuk University, Faculty of Science, Department of Biochemistry, 42075 Konya, Turkey
6Department of Bioengineering, Faculty of Engineering, Marmara University, 34722 Istanbul, Turkey
7Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
8ERNAM – Erciyes University Nanotechnology Application and Research Center, 38039 Kayseri, Turkey
9Department of Materials Science and Engineering, Erciyes University, Kayseri 38039, Turkey
10Department of Chemistry Technology, Technical Vocational School, Aksaray University, 68100 Aksaray, Turkey
11Faculty of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
12Natural History Museum of Denmark, University of Copenhagen, DK-2100 Copenhagen, Denmark
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Elsevier, 2021
Publish Date: 2022-08-14


Porous, bioactive microspheres have always been a dream material to biomedical scientists for bone regeneration and drug delivery applications due to their interconnectivity, unique pore geometry, encapsulation ability and porosity spanning macroscopic, microscopic and nanoscopic length scales. Extensive efforts have been made to produce such materials synthetically at a great cost of money, time and labor. Herein, naturally-assembled multifunctional, open-channeled and hollow bioactive micro silica spheres (diameter 209.4 ± 38.5 µm) were discovered in a marine sponge (Geodia macandrewii), by peeling the outer surface of the sterrasters using hydrogen fluoride. The obtained micro silica spheres exhibited valuable characteristics such as homogeneously distributed pores, a cavity in the center of the sphere, and channels (approx. 3000) opening from each pore into the central cavity. Simulated body fluid analysis demonstrated the bioactivity of the micro silica spheres; whereas, no bioactivity was recorded for the original untreated sterrasters. The non-cytotoxicity and osteogenic ability of the isolated microspheres were confirmed through osteoblast cell culture. Finally, these silica based porous microspheres were tested for controlled drug release capacity. The spheres showed excellent loading and release abilities for an anti-cancer drug, carboplatin, in simulated solutions and in human cancer cell culture, HeLa, through a real time cell analyzer system. The drug loading capacity of the porous beads was determined as 10.59%. Considering the unique biological and physicochemical properties, these novel bioactive silica spheres, which we name as giant macroporous silica (GMS), are promising materials for a range of applications including bone tissue engineering and drug delivery.

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Series: Chemical engineering journal
ISSN: 1385-8947
ISSN-E: 1873-3212
ISSN-L: 1385-8947
Volume: 407
Article number: 126667
DOI: 10.1016/j.cej.2020.126667
Type of Publication: A1 Journal article – refereed
Field of Science: 216 Materials engineering
Copyright information: © 2020 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license