University of Oulu

Vänni, P., Tejesvi, M.V., Ainonen, S. et al. Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome. Sci Rep 11, 17483 (2021). https://doi.org/10.1038/s41598-021-97007-x

Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome

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Author: Vänni, Petri1; Tejesvi, Mysore V.1,2; Ainonen, Sofia1;
Organizations: 1PEDEGO (Pediatrics, Dermatology, Gynecology, Obstetrics) Research Unit and Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland
2Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland
3Department of Paediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
4Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
5Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021101250706
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-10-12
Description:

Abstract

Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. Here, we used the PICRUSt2 bioinformatics tool to predict the functional profiles of the gut microbiome based on 16S sequencing in two child cohorts. Both Caesarean section and perinatal antibiotics markedly influenced the functional profiles of the gut microbiome at the age of 1 year. In machine learning analysis, bacterial fatty acid, phospholipid, and biotin biosynthesis were the most important pathways that differed according to delivery mode. Proteinogenic amino acid biosynthesis, carbohydrate degradation, pyrimidine deoxyribonucleotide and biotin biosynthesis were the most important pathways differing according to antibiotic exposure. Our study shows that both Caesarean section and perinatal antibiotics markedly influence the predicted metabolic profiles of the gut microbiome at the age of 1 year.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 11
Issue: 1
Article number: 17483
DOI: 10.1038/s41598-021-97007-x
OADOI: https://oadoi.org/10.1038/s41598-021-97007-x
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: Financial support was received from Academy of Finland, Finnish Pediatric Research Foundation, University of Oulu Graduate School, and Oulu University Hospital, Finland.
Copyright information: © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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