Vänni, P., Tejesvi, M.V., Ainonen, S. et al. Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome. Sci Rep 11, 17483 (2021). https://doi.org/10.1038/s41598-021-97007-x
Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
|Author:||Vänni, Petri1; Tejesvi, Mysore V.1,2; Ainonen, Sofia1;|
1PEDEGO (Pediatrics, Dermatology, Gynecology, Obstetrics) Research Unit and Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland
2Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland
3Department of Paediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
4Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
5Biocenter Oulu, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 3.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2021101250706
|Publish Date:|| 2021-10-12
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. Here, we used the PICRUSt2 bioinformatics tool to predict the functional profiles of the gut microbiome based on 16S sequencing in two child cohorts. Both Caesarean section and perinatal antibiotics markedly influenced the functional profiles of the gut microbiome at the age of 1 year. In machine learning analysis, bacterial fatty acid, phospholipid, and biotin biosynthesis were the most important pathways that differed according to delivery mode. Proteinogenic amino acid biosynthesis, carbohydrate degradation, pyrimidine deoxyribonucleotide and biotin biosynthesis were the most important pathways differing according to antibiotic exposure. Our study shows that both Caesarean section and perinatal antibiotics markedly influence the predicted metabolic profiles of the gut microbiome at the age of 1 year.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
Financial support was received from Academy of Finland, Finnish Pediatric Research Foundation, University of Oulu Graduate School, and Oulu University Hospital, Finland.
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