University of Oulu

Solomon, Alina et al. ‘Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk’. 1 Jan. 2021 : 1461–1466,

Effect of a multidomain lifestyle intervention on estimated dementia risk

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Author: Solomon, Alina1,2; Handels, Ron3,4,5; Wimo, Anders5;
Organizations: 1Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland
2Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden
3Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
4Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
5Karolinska Institutet, NVS, Division of Neurogeriatrics, Stockholm, Sweden
6Center for Life Course Health Research, University of Oulu, Oulu, Finland
7Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
8Oulu City Hospital, Oulu, Finland
9Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
10Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
11Hospital District of North Karelia, Joensuu, Finland
12University of Helsinki and Helsinki University Hospital, Helsinki, Finland
13Department of Public Health, University of Helsinki, Helsinki, Finland
14National School of Public Health, Madrid, Spain
15Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.1 MB)
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Language: English
Published: IOS Press, 2021
Publish Date: 2021-10-14


We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60–77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was –0.16 (95 %CI –0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04–6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

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Series: Journal of Alzheimer's disease
ISSN: 1387-2877
ISSN-E: 1875-8908
ISSN-L: 1387-2877
Volume: 82
Issue: 4
Pages: 1461 - 1466
DOI: 10.3233/JAD-210331
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: AS received research funding from the European Research Council grant 804371, Academy of Finland (287490, 294061, 319318), Finnish Cultural Foundation, Yrjö Jahnsson Foundation (Finland), Alzheimerfonden and Region Stockholm ALF (Sweden). RA received State research funding (EVO/VTR grants) of Oulu University Hospital and Oulu City Hospital (Finland). HS received funding from EU 7th framework collaborative project grant (HATICE), EU Joint Programme - Neurodegenerative Disease Research (MIND-AD), UEF Strategic funding for UEFBRAIN (Finland), and State research Funding (EVO/VTR grants) from Kuopio University Hospital (Finland). MK received research support from the Academy of Finland (317465), Finnish Social Insurance Institution, Finnish Ministry of Education and Culture, Juho Vainio Foundation (Finland), EU Joint Programme - Neurodegenerative Disease Research (MIND-AD and EURO-FINGERS), Alzheimer’s Research and Prevention Foundation (US), Alzheimerfonden (Sweden), Swedish Research Council, Center for Innovative Medicine (CIMED) at Karolinska Institutet, Region Stockholm (ALF, NSV), Knut and Alice Wallenberg Foundation (Sweden), Stiftelsen Stockholms sjukhem (Sweden), Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse (Sweden). TN received research funding from EU Joint Programme - Neurodegenerative Disease Research (EURO-FINGERS) and Finnish Cultural Foundation, Juho Vainio Foundation; and Jalmari and Rauha Ahokas Foundation, Finland.
Copyright information: © 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the termsof the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).