University of Oulu

Männistö, J., Sammalkorpi, H., Niinimäki, M., Mentula, M. and Mentula, P. (2021), Association of complicated appendicitis on the risk of later in vitro fertilization treatment requirement and ectopic pregnancy: a nationwide cohort study. Acta Obstet Gynecol Scand, 100: 1490-1496. https://doi.org/10.1111/aogs.14165

Association of complicated appendicitis on the risk of later in vitro fertilization treatment requirement and ectopic pregnancy : a nationwide cohort study

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Author: Männistö, Jaana1; Sammalkorpi, Henna2; Niinimäki, Maarit3;
Organizations: 1Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland
2Department of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
31Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland
4Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Women’s Clinic, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2021102552164
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2022-04-24
Description:

Abstract

Introduction: A population-based register study utilizing three Finnish National Registers was carried out to determine whether uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis are associated with a subsequent risk of requiring in vitro fertilization (IVF) treatment or a risk of ectopic pregnancy among reproductive-age women.

Material and methods: A total of 23 997 women who underwent appendectomy for uncomplicated or complicated appendicitis or for nonspecific abdominal pain or who had nonspecific abdominal pain without surgical procedures between 2000 and 2012 were included in the study. The later risks of IVF treatment requirement and ectopic pregnancy were assessed after uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis. Women with nonspecific abdominal pain without surgical procedures served as the reference group.

Results: The rates of later IVF treatment after uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis were low (2.1%, 2.5% and 2.3%, respectively; p = 0.681). Neither appendicitis nor appendectomy was associated with the risk of requiring IVF treatment. The rate of ectopic pregnancy after uncomplicated and complicated appendicitis was very low (0.8%). Women with uncomplicated appendicitis had a significantly lower risk of ectopic pregnancy compared with patients with nonspecific abdominal pain.

Conclusions: Appendicitis, whether complicated or uncomplicated, and appendectomy without appendicitis does not increase the risk of requiring later IVF treatment or the risk of ectopic pregnancy.

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Series: Acta obstetricia et gynecologica Scandinavica
ISSN: 0001-6349
ISSN-E: 1600-0412
ISSN-L: 0001-6349
Volume: 100
Issue: 8
Pages: 1490 - 1496
DOI: 10.1111/aogs.14165
OADOI: https://oadoi.org/10.1111/aogs.14165
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: The study was supported by Oulu University Hospital Research Funds.
Copyright information: © 2021 Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). Published by John Wiley & Sons Ltd. "This is the peer reviewed version of the following article: Männistö, J., Sammalkorpi, H., Niinimäki, M., Mentula, M. and Mentula, P. (2021), Association of complicated appendicitis on the risk of later in vitro fertilization treatment requirement and ectopic pregnancy: a nationwide cohort study. Acta Obstet Gynecol Scand, 100: 1490-1496, which has been published in final form at https://doi.org/10.1111/aogs.14165. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving